664336-96-3Relevant articles and documents
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes
Dong, Yuxiang,Tang, Yuanqing,Chollet, Jacques,Matile, Hugues,Wittlin, Sergio,Charman, Susan A.,Charman, William N.,Tomas, Josefina Santo,Scheurer, Christian,Snyder, Christopher,Scorneaux, Bernard,Bajpai, Saroj,Alexander, Scott A.,Wang, Xiaofang,Padmanilayam, Maniyan,Cheruku, Srinivasa R.,Brun, Reto,Vennerstrom, Jonathan L.
, p. 6368 - 6382 (2006)
Based on the structures of several lipophilic trioxolane antimalarial prototypes, we set out to determine which functional groups were associated with good antimalarial profiles and identify more polar (lower Log P/Log D) lead compounds with good physicoc