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General Description

2,5-Pyrrolidinedione,1-(2-fluoro-2-propenyl)-(9CI) is a chemical compound with the molecular formula C7H7NO2F. It is a derivative of pyrrolidinedione, which is commonly used as a building block in organic synthesis. The compound contains a fluoro-2-propenyl substituent, which makes it useful for introducing fluorinated groups into organic molecules. 2,5-Pyrrolidinedione,1-(2-fluoro-2-propenyl)-(9CI) has potential applications in pharmaceuticals, agrochemicals, and materials science due to its unique chemical properties and potential for introducing fluorine-containing functionality into organic molecules. Further studies are needed to explore its full potential and applications in various fields.

Upstream product

• 123-56-8 Succinimide 

Relevant academic research and scientific papers

Synthesis of vinyl fluorides by ring-closing metathesis

The first ring-closing olefin metatheses of alkenyl α- fluoroacrylamides or acrylates incorporating a fluorinated double bond are reported. Several N-benzyl-N-alkenyl-α-fluoroacrylamides were cyclized in the presence of 2mol% of Grubbs II catalyst at room

Ring-closing metathesis of vinyl fluorides towards α-fluorinated α,β-unsaturated lactams and lactones

Ring-closing olefin metathesis reactions (RCM) using Grubbs II or Hoveyda's catalysts have been applied to a series of N-alkenyl-N-benzyl-α-fluoroacrylamides. α-Fluoro-α,β-unsaturated γ- or δ-lactams incorporating a fluorinated double bond were obtained in moderate to good yields, depending on the nature of substituents on the benzyl ring. The corresponding seven- and eight-membered lactams were not formed under similar conditions. When the N-benzyl group was replaced by an N-tosyl group, the corresponding ε-lactam was also formed in 38% yield. When N-(2-fluoroallyl) derivatives were used instead of fluoroacryloyl derivatives, six-, seven-, and eight-membered N-heterocycles were obtained in low yields. This method was also used to synthesize fluorinated α,β-unsaturated analogues of pyrrolizidine and indolizidine alkaloids from prolinol, and also to synthesize N-benzyl-3-fluoroquinolone in three steps from commercially available 2-vinylaniline in 44% overall yield. Also 3-fluorocoumarin and 3-fluorochromene were prepared from ovinylphenol, and 3-fluoro-benzoxepine was available from o-allylphenol.