66448-76-8Relevant academic research and scientific papers
Palladium-Catalyzed Hydroalkylation of Alkynes with Cyclopropanols: Access to γ,δ-Unsaturated Ketones
Liu, Hao,Fu, Zhiyuan,Gao, Shang,Huang, Yue,Lin, Aijun,Yao, Hequan
, p. 3171 - 3175 (2018)
A palladium-catalyzed hydroalkylation of alkynes with cyclopropanols has been developed. This reaction provided a straightforward way to the synthesis of γ,δ-unsaturated ketones in moderate to good yields, exhibiting high atom economy and Z/E selectivity. Deuterated tri-substituted alkenes could also be expediently produced by using deuterium oxide as a co-solvent. (Figure presented.).
