66449-58-9

Upstream product

• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 112142-72-0 N-benzyloxycarbonyl-L-valyl-N¹,N¹,2-trimethylalanin-amid 
• 259217-26-0 benzyl N-{(1S)-2-methyl-1-[({1,1-dimethyl-2-[methyl(phenyl)amino]-2-oxoethyl}amino)carbonyl]propyl}carbamate 
• 132682-04-3 methyl (S)-2-(2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)-2-methylpropanoate 

Downstream Products

• 128422-21-9 Z-Val-Aib-Aib-NMe₂ 
• 84758-75-8 N-benzyloxycarbonyl-valyl-2-methylalanylglycin-(tert-butyl)ester 
• 259217-27-1 methyl (2S)-2-[2-((2S)-{[(benzyloxy)carbonyl]amino}-3-methylbutanamido)-3-methylpropanamido]-4-methylpentanoate 
• 259217-28-2 methyl (2S)-1-(2-{(2S)-2-[2-((2S)-{[(benzyloxy)carbonyl]amino}-3-methylbutanamido)-2-methylpropanamido]-4-methylpentanamido}-2-methylpropanoyl)pyrrolidine-2-carboxylate 
• 128422-19-5 Val-Aib-Aib-NMe(Ph) 
• 128422-10-6 Pro-Val-Aib-Aib-NMe(Ph) 
• 71890-87-4 N-phenylmethoxycarbonyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanine 
• 128422-26-4 Z-Pro-Val-Aib-Aib-NMe₂ 
• 128422-25-3 Z-Pro-Val-Aib-Aib-NMe(Ph) 
• 128422-23-1 Z-Leu-Aib-Pro-Val-Aib-Aib-OH 
• 128422-08-2 Z-Leu-Aib-Pro-Val-Aib-Aib-NMe(Ph) 
• 128422-16-2 Fmoc-Leu-Aib-Pro-Val-Aib-Aib-NMe(Ph) 
• 128422-09-3 Z-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Pheol 

Relevant academic research and scientific papers

Synthesis of tripeptides containing heterocyclic α -amino acids by using heterospirocyclic 3-amino-2H-azirines

By using the 'azirine/oxazolone method', di- and tripeptides containing six-membered heterocyclic 4-amino-4-carboxylic acids with a piperidine, tetrahydropyran or tetrahydrothiopyran ring have been synthesized. It has been shown that the corresponding het

Synthesis of endothiopeptides and their cyclization to 1,3-thiazol- 5(4H)-imines

Further investigations of the synthesis of endothio analogues of the segment 1-10 (8) of an apolar analogon of zervamicin IIA are described. The endothiodecapeptide Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Ψ(CS)-Pro-OMe (10) has been prepared in good yield

Efficient synthesis of alamethicin F-30 using a chloro imidazolidium coupling reagent, CIP

Alamethicin F-30 has been synthesized in solution using a CIP-additive as a coupling agent and TFA as a final deprotecting reagent. All couplings including those between sterically hindered α,α-dimethyl amino acid were successfully achieved by a 60 min re

Selective Amide Cleavage in Peptides Containing α,α-Disubstituted α-Amino Acids

A new synthesis of dipeptides with terminal α,α-disubstituted α-amino acids, using 2,2-disubstituted 3-amino-2H-azirines 1 as amino-acid equivalents, is demonstrated.The reaction of 1 with N-protected amino acids leads to the corresponding dipeptide amide