66488-79-7

Usage

Uses

Used in Fragrance Industry:
4-ISOBUTOXY-3-METHOXYBENZALDEHYDE is used as a fragrance ingredient for its sweet, floral scent in various consumer products, including perfumes, soaps, and cosmetics.
Used in Flavoring Industry:
4-ISOBUTOXY-3-METHOXYBENZALDEHYDE is also used in the production of flavorings, contributing to the unique taste and aroma of food and beverage products.
Used in Organic Synthesis:
4-ISOBUTOXY-3-METHOXYBENZALDEHYDE serves as a precursor in organic synthesis, playing a crucial role in the creation of various chemical compounds and intermediates.
It is important to handle 4-ISOBUTOXY-3-METHOXYBENZALDEHYDE with care, as it can be irritating to the skin, eyes, and respiratory system. Proper safety measures should be taken during its use in different applications.

InChI:InChI=1/C12H16O3/c1-9(2)8-15-11-5-4-10(7-13)6-12(11)14-3/h4-7,9H,8H2,1-3H3

Upstream product

• 121-33-5 vanillin 
• 513-36-0 isobutyryl chloride 
• 78-77-3 Isobutyl bromide 

Downstream Products

• 1383744-30-6 N-(tert-butyloxycarbonyl)-N'-(4-(2-methylpropyloxy)-3-methoxy-benzyl)piperazine 
• 66488-82-2 4-(4-isobutoxy-3-methoxy-benzylidene)-2-phenyl-4H-oxazol-5-one 
• 3535-35-1 4-isobutoxy-3-methoxy benzoic acid 
• 744243-58-1 (E)-3-(4-isobutoxy-3-methoxyphenyl)acrylic acid 
• 902745-25-9 3-amino-3-(4-isobutoxy-3-methoxy-phenyl)-propionic acid 

Relevant academic research and scientific papers

Potent human dihydroorotate dehydrogenase inhibitory activity of new quinoline-4-carboxylic acids derived from phenolic aldehydes: Synthesis, cytotoxicity, lipophilicity and molecular docking studies

A series of novel 2-substituted quinoline-4-carboxylic acids was synthesized by Doebner reaction starting from freely available protocatechuic aldehyde and vanillin precursors. Human dihydroorotate dehydrogenase (hDHODH) was recognised as a clear molecular target for these heterocycles. All compounds were also tested for their antiproliferative potential against three cancer cells (MCF-7, A549, A375) and one normal cell line (HaCaT) to evaluate the selective cytotoxicity. Quinoline derivatives 3f and 3g were identified as potent hDHODH inhibitors while 3k and 3l demonstrated high cytotoxic activity against MCF-7 and A375 cells and good selectivity. In addition, the logD7.4 values obtained by the experimental method were found to be in the range from ?1.15 to 1.69. The chemical structures of all compounds were confirmed by IR, NMR and elemental analysis. The compounds pharmacology on the molecular level was revealed by means of molecular docking, highlighting the structural differences that distinguish highly active from medium and low active hDHODH inhibitors.

First Discovery of Novel Pyrido[1,2- a]pyrimidinone Mesoionic Compounds as Antibacterial Agents

Plant bacterial diseases cause tremendous decreases in crop yield and quality, and there is a lack of highly effective and low-risk antibacterial agents. A series of novel pyrido[1,2-a]pyrimidinone mesoionic compounds containing vanillin moieties were synthesized, and the application of these mesoionic compounds as plant antibacterial agents was reported here for the first time. The bioassay results revealed that the mesoionic compounds had good antibacterial activity. Of these compounds, compound 11 showed excellent in vitro activity against Xanthomonas oryzae pv. oryzae, with an EC50 value of 1.1 μg/mL, which was substantially better than that of bismerthiazol (92.7 μg/mL) and thiodiazole copper (105.4 μg/mL). Moreover, greenhouse condition trials indicated that the protective and curative activities of compound 11 against rice bacterial leaf blight were 75.12 and 72.04%, respectively, which were better than those of bismerthiazol (62.24 and 50.83%, respectively) and thiodiazole copper (53.35 and 65.04%, respectively). These results provide a basis for the application of mesoionic vanillin moieties as new antibacterial agents.

N,N+hu 1 +l SUBSTITUTED PIPERAZINES HAVING COMBINED ANTIAGGREGANT, ANTICOAGULANT AND VASODILATORY ACTIVITY, AND METHOD FOR PRODUCING SAME

The invention relates to derivatives of N,N′-substituted piperazines of the general formula (I): where R1 and R2 denote linear or branched (C1-C4)alkyl, linear or branched (C1-C4)alkoxy, CH

Competitive formation of β-amino acids, propenoic, and ylidenemalonic acids by the Rodionov reaction from malonic acid, aldehydes, and ammonium acetate in alcoholic medium

The Rodionov reaction of 49 available aliphatic and aromatic aldehydes with malonic acid and ammonium acetate in alcoholic medium, resulting in formation of β-amino acids, propenoic, and ylidenemalonic acids, was studied. Certain regioselectivity regularities of the reaction were revealed. Among the variety of ketones studied, cyclohexanone is the only whose reaction yields a β-amino acid. Unusual dehydrofluorination of 6-chloro-2-fluorocinnamic acid under the Rodionov reaction was discovered. 2005 Pleiades Publishing, Inc.