66490-33-3

Basic information

• Product Name: 4-chloro- Benzo[b]thiophene
• Synonyms: 4-chloro- Benzo[b]thiophene;Benzo[b]thiophene, 4-chloro-;4-Chlorobenzothiophene;4-chloro-1-benzothiophene
• CAS NO: 66490-33-3
• Molecular Formula: C₈H₅ClS
• Molecular Weight: 168.6433
• EINECS: -0
• Mol File: 66490-33-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 81-82 °C
• Boiling Point: 0.8 °C(Press: 155-165 Torr)
• Appearance: /
• Density: 1.349±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Acetone (Slightly), Chloroform (Slightly)
• CAS DataBase Reference: 4-chloro- Benzo[b]thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro- Benzo[b]thiophene(66490-33-3)
• EPA Substance Registry System: 4-chloro- Benzo[b]thiophene(66490-33-3)

Safety Data

• Hazardous Substances Data: 66490-33-3(Hazardous Substances Data)

Usage

Uses

4-Chlorobenzothiophene is an intermediate used to prepare 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism.

Upstream product

• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 180160-64-9 (m-Chlor-phenyl-mercapto)-acetaldehyd-diaethyl-acetal 
• 205054-85-9 1-chloro-3-(2,2-dimethoxyethylsulfanyl)benzene 
• 17402-83-4 benzo[B]thiophen-4-ylamine 

Downstream Products

• 846038-18-4 1-benzo[b]thiophen-4-ylpiperazine hydrochloride 
• 1420987-86-5 C₂₀H₁₈N₂S₂ 
• 913611-97-9 Brexpiprazole 
• 1191901-07-1 tert-butyl 4-(benzo[b]thiophen-4-yl)piperazine-1-carboxylate 
• 17347-34-1 benzo[b]thiophene-4-carbonitrile 
• 10134-95-9 benzothiophen-4-carboxic acid 

Relevant articles and documents

Unexpected formation of 4,7-dihalobenzo[b]thiophenes using Ohira-Bestmann reagent and reactivity of the halogen-substituted benzo[b]thiophenes in Suzuki-Miyaura coupling with phenylboronic acid

Reaction of 2-(1-adamantylsulfanyl)-3,6-dihalobenzaldehydes with Ohira-Bestmann reagent gave 4,7-dihalobenzo[b]thiophenes along with normal alkyne products. Nine types of 4,7-dihalobenzo[b]thiophenes bearing chlorine, bromine, or iodine atoms, were prepared by this method. Regioselectivity in Suzuki-Miyaura cross coupling reactions of the 4,7-dihalobenzo[b]thiophenes with PhB(OH)2 was also studied.

Substituted oxoazaheterocyclyl compounds

This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa..