664985-99-3

Upstream product

• 98-10-2 benzenesulfonamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 

Downstream Products

• 115377-87-2 N-((4-methoxyphenyl)(p-tolyl)methyl)benzenesulfonamide 
• 217947-27-8 N-[1-(4-methoxyphenyl)-3-butenyl]benzenesulfonamide 

Relevant academic research and scientific papers

Silica-supported zinc chloride (ZnCl2/SiO2)-induced efficient protocol for the synthesis of N-sulfonyl imines and 2-Arylbenzothiazole

A straightforward strategy for the synthesis of N-sulfonyl imine derivatives from sulfonamides and aryl aldehydes utilizing Silica-supported zinc chloride (ZnCl2/SiO2, silzic) as a catalyst under solvent-free conditions has been developed. 2-Arylbenzothiazole derivatives were also synthesized by the reaction of 2-aminothiophenol with aryl aldehydes under the same conditions. This procedure has advantages of high yields, mild reaction condition, simple procedure, low cost, and simplicity of workup. The catalyst has the same efficiency on its reuse up to three times.

γcarbon Activation through N-Heterocyclic Carbene/Bronsted Acids Cooperative Catalysis: A Highly Enantioselective Route to γlactams

A carbon activation method that operates through N-heterocyclic carbene/Bronsted acid cooperative catalysis for highly enantioselective synthesis of γlactams is reported. The protocol allows the challenging remote carbon control of regioselectivity and en

Cyanuric chloride-catalyzed synthesis of N-sulfonyl imines

Cyanuric chloride is an inexpensive, efficient, and mild catalyst for the synthesis of N-sulfonyl imines by the reaction of sulfonamides with aryl aldehydes at 110°C under solvent-free conditions. This method affords the N-sulfonyl imines in short reactio

Small-molecule inhibitors of protein geranylgeranyltransferase type I

Small molecules that inhibit the geranylgeranylation of K-Ras4B and RhoA by protein geranylgeranyltransferase type I (GGTase-I) were identified from chemical genetic screens of heterocycles synthesized through phosphine catalysis of allenes. To further improve the efficacy of the GGTase-I inhibitors (GGTIs), 4288 related compounds bearing core dihydropyrrole/pyrrolidine and tetrahydropyridine/piperidine scaffolds were synthesized on SynPhase lanterns in a split-pool manner through phosphine-catalyzed [3 + 2] and [4 + 2] annulations of resin-bound allenoates. Testing of the 4288 analogues resulted in several GGTIs exhibiting submicromolar IC50 values. Because proteins such as Ras and Rho GTPases are implicated in oncogenesis and metastasis, these GGTIs might ultimately lead to the development of novel antitumor therapeutics. Copyright

Synthesis of 2-chloro-2-imidoylaziridines via aza-darzens-type reaction of 3,3-dichloro-1-azaallylic anions and N-(arylsulfonyl)imines

3,3-Dichloro-1-azaallylic anions, generated by deprotonation of α,α-dichloroketimines 10 with lithium diisopropylamide, reacted with N-sulfonylaldimines 7 to produce the Mannich-type products N-[2,2-dichloro-3- (N-alkylimino)-1,3-diarylpropyl]benzenesulfo

An efficient and convenient procedure for preparation of N-sulfonylimines catalysed by TiO2/SO42- solid superacid

A facile synthesis of N-sulfonylimines in good to excellent yields was described from aldehydes with sulfonamides catalysed by TiO2/SO 42- solid superacid.