66499-24-9

Basic information

• Product Name: Benzeneethanesulfinic acid
• CAS NO: 66499-24-9
• Molecular Formula: C8H10O2S
• Molecular Weight: 170.232
• Mol File: 66499-24-9.mol

Chemical Properties

• CAS DataBase Reference: Benzeneethanesulfinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanesulfinic acid(66499-24-9)
• EPA Substance Registry System: Benzeneethanesulfinic acid(66499-24-9)

Safety Data

• Hazardous Substances Data: 66499-24-9(Hazardous Substances Data)

Upstream product

• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 143769-64-6 2-Phenyl-ethanesulfonic acid phenethyl-amide 
• 76653-10-6 N-phenyl-β-phenethylsulfonamide 
• 104216-42-4 3-phenethylmercapto-propionic acid 
• 23293-03-0 triphenethylaluminum 
• 358972-26-6 3-(2-phenyl-ethanesulfonyl)-propionic acid 

Downstream Products

• 16993-47-8 2-(phenyl)ethanesulfonamide 

Relevant articles and documents

Reductive Cleavage of Secondary Sulfonamides: Converting Terminal Functional Groups into Versatile Synthetic Handles

Sulfonamides are pervasive in pharmaceuticals and agrochemicals, yet they are typically considered as terminal functional groups rather than synthetic handles. To enable the general late-stage functionalization of secondary sulfonamides, we have developed a mild and general method to reductively cleave the N-S bonds of sulfonamides to generate sulfinates and amines, components which can further react in situ to access a variety of other medicinally relevant functional groups. The utility of this platform is highlighted by the selective manipulation of several complex bioactive molecules.