66504-62-9

Basic information

• Product Name: Benzeneacetic acid, 4-chloro-3-(trifluoromethyl)-, methyl ester
• CAS NO: 66504-62-9
• Molecular Formula: C10H8ClF3O2
• Molecular Weight: 252.621
• Mol File: 66504-62-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 4-chloro-3-(trifluoromethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 4-chloro-3-(trifluoromethyl)-, methyl ester(66504-62-9)
• EPA Substance Registry System: Benzeneacetic acid, 4-chloro-3-(trifluoromethyl)-, methyl ester(66504-62-9)

Safety Data

• Hazardous Substances Data: 66504-62-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 22902-86-9 2-[4-chloro-3-(trifluoromethyl)phenyl]acetic acid 

Downstream Products

• 1204593-42-9 dimethyl 5-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxycyclohex-3-ene-1,3-dicarboxylate 
• 1204593-51-0 methyl 2-(4-chloro-3-(trifluoromethyl)-phenyl)propanoate 
• 873011-69-9 tert-butyl 2-hydroxy-6-[({4'-[(methoxycarbonyl)methyl]-2'-trifluoromethyl-1,1'-biphenyl-4-yl}oxy)methyl]-3-(trifluoromethyl)benzoate 
• 66504-64-1 (1R,2S)-1-(4-Chloro-3-trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid dimethyl ester 
• 66504-65-2 (1R,2S)-1-(4-Chloro-3-trifluoromethyl-phenyl)-cyclopropane-1,2-dicarboxylic acid 
• 66504-66-3 1-(4-Chlor-3-trifluormethyl-phenyl)-1,2-cyclopropan-dicarboximid 
• 86215-43-2 1-(4-Chloro-α,α,α-trifluoro-m-tolyl)-3-azabicyclo[3.1.0]hexane 
• 66504-63-0 Bromo-(4-chloro-3-trifluoromethyl-phenyl)-acetic acid methyl ester 

Relevant articles and documents

BENZENE COMPOUND HAVING 2 OR MORE SUBSTITUENTS

A superior LXR modulator is provided. A compound represented by the general formula (I): [wherein R1: -COR9 (wherein R9: alkyl, optionally substituted alkoxy or optionally substituted amino); R2: H, OH, alkoxy, optionally substituted amino, etc.; R3: H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogeno, etc.; R4 and R5: H, optionally substituted alkyl, halogeno, etc.; R6 and R7: H, alkyl; R8: -X2R10 [wherein R10: -COR11 (wherein R11 : OH, optionally substituted alkoxy, optionally substituted amino, etc.), -SO2R12 (wherein R12: optionally substituted alkyl, optionally substituted amino, etc.), tetrazol-5-yl, etc.; X2: single bond, optionally substituted alkylene, etc.]; X1: -NH-, -O-, -S-, etc.; Y1: optionally substituted phenyl, optionally substituted 5- to 6-membered aromatic heterocyclyl; Y2: optionally substituted aryl, optionally substituted heterocyclyl, etc.] and the like is provided.

BENZENE COMPOUND HAVING 2 OR MORE SUBSTITUENTS

Disclosed is an excellent LXR modulator. Specifically disclosed is a compound represented by the general formula (I) below or the like. (I) [In the formula, R1 represents a -COR9 (wherein R9 represents an alkyl, optionally substituted alkoxy or optionally substituted amino); R2 represents an H, OH, alkoxy, optionally substituted amino or the like; R3 represents an H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogeno or the like; R4 and R5 respectively represent an H, optionally substituted alkyl, halogeno or the like; R6 and R7 respectively represent an H or alkyl; R8 represents a -X2R10 [wherein R10 represents a -COR11 (wherein R11 represents an OH, optionally substituted alkoxy, optionally substituted amino or the like), -SO2R12 (wherein R12 represents an optionally substituted alkyl, optionally substituted amino or the like), tetrazole-5-yl or the like; and X2 represents a single bond, optionally substituted alkylene or the like]; X1 represents an -NH-, -O-, -S- or the like; Y1 represents an optionally substituted phenyl or optionally substituted 5-membered or 6-membered aromatic heterocyclyl; and Y2 represents an optionally substituted aryl, substituted heterocyclyl or the like.]