66513-49-3

Upstream product

• 1460-57-7 trans-1,2-cyclohexandiol 
• 10234-40-9 2,2'-(1,2-phenylenedioxy)diethanol 
• 15128-65-1 dicyclohexano-18-crown-6 
• 58774-61-1 cis-1,2-Cyclohexandioxydiessigsaeure 
• 1792-81-0 cis-1,2-cyclohexane 
• 120-80-9 benzene-1,2-diol 
• 98449-71-9 meso-diethyl 2,2'-[cyclohexane-1,2-diylbis(oxy)]diacetate 

Downstream Products

• 98449-72-0 (((1R,2S)-cyclohexane-1,2-diyl)bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) 

Relevant academic research and scientific papers

MACROCYCLIC CHELATORS AND METHODS OF USE THEREOF

Macrocyclic chelators (I) for chelation of alpha-emitting radiometal ions, such as actinium-225 are provided. Also provided are radiometal complexes containing an alpha-emitting radiometal ion bound to the macrocyclic chelator via coordinate bonding, and radioimmunoconjugates containing the radiometal complexes covalently linked to a targeting ligand, such as an antibody or antigen binding fragment thereof. The radioimmunoconjugates can be produced by click chemistry reactions. Methods of using the radiocomplexes and radioimmunoconjugates for selectively targeting neoplastic cells for radiotherapy and for treating neoplastic diseases and disorders are also described.

Radiochemical stability of the dicyclohexano-18-crown-6 ether (DCH18C6): Synthesis and tests in radioactive medium of the DCH18C6 radiolytic products

The cis-syn-cis isomer of the dicyclohexano-18-crown-6 ether (DCH18C6) was subjected to hydrolysis and radiolysis with a 137Cs gamma source, at different doses of irradiation. The cis-syn-cis DCH18C6 radiolytic products previously identified [1], were synthesized in their different configurations. These radiolytic products, all of cis configuration, were tested on aqueous synthetic solutions of spent nuclear fuels. Experiments in radioactive medium showed that, under continuous extraction conditions, the cis-syn-cis DCH18C6 radiolytic products cannot perturb a reprocessing process using the DCH18C6 as selective extractant. Good prospects for the application of DCH18C6 to spent nuclear fuel reprocessing were therefore demonstrated. An X-ray crystallographic study of the DCH18C6 cis-syn-cis-isomer with uranyl nitrate was investigated. Elsevier,.

Phase-Transfer-Catalyzed Synthesis of Oligoethylene Glycols and Derivatives

An efficient, two-step synthetic method for the addition of ethyleneoxy units to diols is reported.Reaction of HOROH with Cl(CH2CH2O)nTHP and 50percent aqueous NaOH in the presence of a phase-transfer catalyst gives THP(OCH2CH2)nORO(CH2CH2O)nTHP from which the protecting groups are readily removed to provide H(OCH2CH2)nORO(CH2CH2O)n in good-to-excellent yields.The influence of reactant diol structure upon yield has been determined.

Synthesis of Cylindrical Large Ring Crown Hosts

New cylindrical crown hosts, tridecalino-27-crown-9, tridecalino-21-crown-7, didecalino-cyclohexano-21-crown-7, and didecalino-21-crown-7 have been synthesize.