66521-58-2 Usage
General Description
(Z)-3-((dimethylamino)methylene)-1-methylpiperidin-4-one, also known as DMAMe-1-piperidin-4-one, is a chemical compound with the molecular formula C10H18N2O. It is a piperidine derivative and a psychoactive compound that acts as a stimulant. This chemical is known for its effects on the central nervous system, including increasing energy, alertness, and concentration. It is often used as a recreational drug and has been associated with adverse effects such as increased heart rate, elevated blood pressure, and potential for addiction. (Z)-3-((dimethylamino)methylene)-1-methylpiperidin-4-one has also been found in various illicit substances and is listed as a controlled substance in some countries.
Check Digit Verification of cas no
The CAS Registry Mumber 66521-58-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,5,2 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 66521-58:
(7*6)+(6*6)+(5*5)+(4*2)+(3*1)+(2*5)+(1*8)=132
132 % 10 = 2
So 66521-58-2 is a valid CAS Registry Number.
66521-58-2Relevant articles and documents
Selective α-Methylation of Ketones
Frolov, Andriy I.,Ostapchuk, Eugeniy N.,Pashenko, Alexander E.,Chuchvera, Yaroslav O.,Rusanov, Eduard B.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.
, p. 7333 - 7346 (2021/06/28)
The convenient and scalable preparative approach for the two-step α-methylation of ketones is described. The optimized protocols for regioselective preparation of enaminones with further diastereoselective and functional groups tolerant hydrogenation to α-methylketones are developed. The scope and limitations of the proposed methodology are discussed. The advantages compared to known procedures are demonstrated. The unexpected role of acetone in the hydrogenation is suggested. The evaluation of the method for both early building block synthesis and late-stage CH-functionalization is shown. The elaborate procedures' preparability and scalability are demonstrated by the synthesis of several α-methyl ketones up to 100 g amount.
