66522-52-9 Usage
General Description
5'-sulfamoyl-2-chloroadenosine is a synthetic chemical compound that is derived from adenosine, a nucleoside that is found in all living cells. It has a sulfamoyl group and a chlorine atom attached to the adenosine molecule. 5'-sulfamoyl-2-chloroadenosine has been studied for its potential pharmaceutical applications, particularly as an antiviral and antiparasitic agent. It has also been investigated for its potential to inhibit angiogenesis, the formation of new blood vessels, which is important in the progression of diseases like cancer. The specific chemical structure of 5'-sulfamoyl-2-chloroadenosine allows it to interact with various proteins and receptors in the body, leading to potential therapeutic effects. However, further research is needed to fully understand its mechanisms of action and potential uses in medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 66522-52-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,5,2 and 2 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 66522-52:
(7*6)+(6*6)+(5*5)+(4*2)+(3*2)+(2*5)+(1*2)=129
129 % 10 = 9
So 66522-52-9 is a valid CAS Registry Number.
66522-52-9Relevant articles and documents
Hexafluoroisopropyl sulfamate: A useful reagent for the synthesis of sulfamates and sulfamides
Sguazzin, Matthew A.,Johnson, Jarrod W.,Magolan, Jakob
supporting information, p. 3373 - 3378 (2021/05/10)
Sulfamates and sulfamides are most often synthesized from alcohols and amines with sulfamoyl chloride, which is an unstable reagent. We have identified hexafluoroisopropyl sulfamate (HFIPS) as a bench-stable solid that reacts readily with a wide variety of alcohols, amines, phenols, and anilines under mild reaction conditions. The sole byproduct of the reaction is hexafluoroisopropanol (HFIP) and reaction products can often be isolated in high purity after an aqueous workup (optional) and removal of solvents by evaporation.
A Novel Synthesis of Sulfamoyl Nucleosides
Kristinsson, Haukur,Nebel, Kurt,O'Sullivan, Anthony C.,Struber, Fritz,Winkler, Tammo,Yamaguchi, Yasuchika
, p. 6825 - 6838 (2007/10/02)
The sulfamoylated ribose derivative 8 was prepared on a kilogram scale, and used in conjunction with various heterocycles to prepare a series of natural and unnatural 5-O-sulfamoyl nucleosides (10 - 32).A modification of the Vorbrueggen-Hilbert-Johnson reaction conditions for nucleoside formation was used.
