6653-80-1

Usage

Uses

Used in Organic Synthesis:
1-(CHLOROMETHYL)-4-ETHOXYBENZENE is used as a precursor in organic synthesis for the production of various chemicals. Its unique structure allows for further chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-(CHLOROMETHYL)-4-ETHOXYBENZENE is used as a chemical intermediate for the development of new drugs. Its reactivity and functional groups make it suitable for the synthesis of pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Industry:
1-(CHLOROMETHYL)-4-ETHOXYBENZENE also finds applications in the agrochemical industry, where it is utilized as a starting material for the synthesis of agrochemicals such as pesticides and herbicides. Its properties contribute to the development of effective crop protection products.
Safety Precautions:
Given the potentially hazardous nature of 1-(CHLOROMETHYL)-4-ETHOXYBENZENE, it is crucial to exercise proper safety measures during its handling and use. This includes adhering to guidelines for chemical storage, handling, and disposal, as well as using appropriate personal protective equipment to minimize health and environmental risks.

InChI:InChI=1/C9H11ClO/c1-2-11-9-5-3-8(7-10)4-6-9/h3-6H,2,7H2,1H3

Upstream product

• 6214-44-4 4-ethoxybenzyl alcohol 
• 622-60-6 1-ethoxy-4-methylbenzene 
• 106-44-5 p-cresol 
• 10031-82-0 4-ethoxybenzaldehyde 
• 50-00-0 formaldehyd 
• 103-73-1 Phenetole 

Downstream Products

• 91339-31-0 1-(4-ethoxyphenyl)-N,N-dimethylmethanamine 
• 6775-77-5 4-ethoxyphenylacetonitrile 
• 515871-35-9 ((4S,5S)-5-{[Bis-(4-ethoxy-benzyl)-amino]-methyl}-2-tert-butyl-2-methyl-[1,3]dioxolan-4-ylmethyl)-bis-(4-ethoxy-benzyl)-amine 
• 515871-62-2 ((4S,5S)-5-{[Bis-(4-ethoxy-benzyl)-amino]-methyl}-2,2-dipropyl-[1,3]dioxolan-4-ylmethyl)-bis-(4-ethoxy-benzyl)-amine 
• 23009-32-7 bis-(4-ethoxy-benzyl)-ethyl-amine 
• 69743-35-7 (4-ethoxybenzyl)triphenylphosphonium chloride 
• 910798-31-1 5-(4-ethoxybenzyl)-8-[(4-methylpiperidin-1-yl)carbonyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 1224715-24-5 N-(1-{5-[(4-ethoxybenzyl)sulfanyl]-1-benzofuran-2-yl}ethyl)acetamide 
• 1224715-36-9 N-(1-{5-[(4-ethoxybenzyl)oxy]-1H-benzimidazol-2-yl}ethyl)acetamide 
• 1224715-01-8 N-(1-{5-[(4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)acetamide 
• 1224715-00-7 N-(1-{5-[(4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)acetamide 

Relevant academic research and scientific papers

In vitro study and structure-activity relationship analysis of stilbenoid derivatives as powerful vasorelaxants: Discovery of new lead compound

The development of vasorelaxant as the antihypertensive drug is important as it produces a rapid and direct relaxation effect on the blood vessel muscles. Resveratrol (RV), as the most widely studied stilbenoid and the lead compound, inducing the excellent vasorelaxation effect through the multiple signalling pathways. In this study, the in vitro vascular response of the synthesized trans-stilbenoid derivatives, SB 1-8e were primarily evaluated by employing the phenylephrine (PE)-precontracted endothelium-intact isolated aortic rings. Herein we report trans-3,4,4′-trihydroxystilbene (SB 8b) exhibited surprisingly more than 2-fold improvement to the maximal relaxation (Rmax) of RV. This article also highlights the characterization of the aromatic protons in terms of their unique splitting patterns in 1H NMR.

COMPLEX OF NONIONIC IODINE CONTRAST MEDIUM

PROBLEM TO BE SOLVED: To provide a novel iodine contrast medium that can reduce nephrotoxicity. SOLUTION: The present invention provides a complex of a nonionic iodine contrast medium and a group recognized by a hepatocyte-specific transporter. SELECTED D

Gadolinium Complex of 1,4,7,10-Tetraazacyclododecane-1,4,7-Trisacetic Acid (DO3A)-Ethoxybenzyl (EOB) Conjugate as a New Macrocyclic Hepatobiliary MRI Contrast Agent

We report the synthesis of a macrocyclic Gd chelate based on a 1,4,7,10-Tetraazacyclododecane-1,4,7-Trisacetic acid (DO3A) coordinationn cage bearing an ethoxybenzyl (EOB) moiety and discuss its use as a T1 hepatobiliary magnetic resonance imaging (MRI) contrast agent. The new macrocyclic liver agent shows high chelation stability and high r1 relaxivity compared with linear-Type Gd chelates, which are the current clinically approved liver agents. Our macrocyclic, liver-specific Gd chelate was evaluated in vivo through biodistribution analysis and liver MRI, which demonstrated its high tumor detection sensitivity and suggested that the new Gd complex is a promising contrast agent for liver cancer imaging.

Preparation method of dapagliflozin intermediate

The invention provides a preparation method of a dapagliflozin intermediate. The preparation method comprises the following steps: (1) by taking 4-methylphenol and bromoethane as raw materials, a polar solvent as a reaction solvent and an inorganic base as a catalyst, carrying out reaction for preparing 4-ethyoxyl methylbenzene; (2) by taking N-chlorosuccinimide and 4-ethyoxyl methylbenzene obtained in the step (1) as raw materials, a non-polar solvent as a reaction solvent and dibenzoyl peroxide as an initiator, carrying out reaction, thus obtaining 4-ethyoxyl benzyl chloride; (3) dissolving 4-ethyoxyl benzyl chloride obtained in the step (2) and 4-bromaniline into ethyl acetate, adding a catalyst lewis acid, and carrying out reaction, thus obtaining 5-bromo-2-amino-4-ethyoxyl diphenylmethane; and (4) carrying out diazotization reaction on 5-bromo-2-amino-4-ethyoxyl diphenylmethane obtained in the step (3), and then reacting with cuprous chloride, thus synthesizing 5-bromo-2-chloro-4'-ethyoxyl diphenylmethane. The preparation method provided by the invention has the advantages of low cost, low environmental stress and short synthetic route.

BICYCLIC COMPOUND

The present invention provides a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer and the like, and has superior efficacy. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Amphiphilic dendritic dipeptides and their self-assembly into helical pores

An amphiphilic dendritic dipeptide, comprises a dipeptide(s) comprising one or more of a naturally occurring or synthetic amino acids and a dendron. These are suitable for use in various formulations, films, coatings, membranes and sensors, among other ap

NOVEL TETRAHYDRO-1H-PYRIDO [4,3-b] INDOLE DERIVATIVES AS CB1’ RECEPTOR LIGANDS

Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Design, synthesis and antiproliferative activity of tripentones: A new series of antitubulin agents

Structure-activity relationship studies of a new series of tripentones (thieno[2,3-b]pyrrolizin-8-ones), led us to prepare several derivatives with antiproliferative activities. The most promising 3-(3-hydroxy-4-methoxyphenyl)thieno[2,3-b]pyrrolizin-8-one 20 (leukemia L1210, IC50 = 15 nM) was shown to be a potent inhibitor of tubulin polymerization.

Insecticidal alkenes

Compounds of formula R3 --CH=CH--CR1 R2 --CH2 OCH2 R4 wherein R1 and R2 are H, alkyl or together form a cycloalkyl group with the adjacent carbon, R3 is a substituted phenyl group, R4 is an optionally substituted phenoxy phenyl group, and compositions containing them useful as insecticides, and compounds of formula HOCH2 --CR1 R2 --CH2 OCH2 R4 and OCH--CR1 R2 CH2 OCH2 R4, useful as intermediates therefor.

Insecticidal alkenes

Compounds of formula R3 --CH=CH--CR1 R2 --CH2 OCH2 R4 wherein R1 and R2 are H, alkyl or together form a cycloalkyl group with the adjacent carbon, R3 is a substituted phenyl group, R4 is an optionally subsituted phenoxy phenyl group, and compositions containing them useful as insecticides, and compounds of formula HOCH2 --CR1 R2 --CH2 OCH2 R4 and OCH--CR1 R2 CH2 OCH2 R4, useful as intermediates therefor.