66530-13-0

Basic information

• Product Name: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-chloro-cyclohexyl ester
• Synonyms: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-chloro-cyclohexyl ester
• CAS NO: 66530-13-0
• Molecular Weight: 350.765
• Mol File: 66530-13-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-chloro-cyclohexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-chloro-cyclohexyl ester(66530-13-0)
• EPA Substance Registry System: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,2S)-2-chloro-cyclohexyl ester(66530-13-0)

Safety Data

• Hazardous Substances Data: 66530-13-0(Hazardous Substances Data)

Upstream product

• 931-13-5 cis-(1R,2S)-2-chlorocyclohexanol 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 
• 1561-86-0 2-chlorocyclohexanol 

Relevant articles and documents

Enzymatic preparation of (1S,2R)- and (1R,2S)-stereoisomers of 2-halocycloalkanols

The stereoisomers of cis-2-halocycloalkanols were resolved by a kinetically controlled transesterification with vinyl acetate in the presence of lipases in organic media. High enantioselectivities (ee >98%) and good isolated yields were obtained for all substrates using the appropriate lipase. Burkholderia cepacia lipase was the most efficient enzyme for the resolution of these substrates. The enantiomeric purities of the compounds were defined by derivatization with Mosher's acid and the absolute configurations were determined by chemical correlation.