66530-55-0Relevant academic research and scientific papers
ION CHANNEL MODULATORS
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Paragraph 00376, (2019/12/25)
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.
PYRROLOPYRROLONE DERIVATIVES AND THEIR USE AS BET INHIBITORS
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Page/Page column 192, (2015/06/08)
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Pyrazolopyrrolidine Derivatives and their Use in the Treatment of Disease
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Paragraph 1045; 1046, (2014/12/09)
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
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Page/Page column 216, (2014/12/12)
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
IMIDAZOPYRROLIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
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Page/Page column 72; 86, (2014/12/12)
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Nucleophilic substitution and lipophilicity - Structure relations in methylazolopyridazines
Katrusiak, Anna,Ratajczak-Sitarz, Malgorzata,Skierska, Urszula,Zinczenko, Wiktoria
, p. 1372 - 1386 (2007/10/03)
Syntheses of methyl[1,2,4]triazolo- or methyltetrazolopyridazine isomers, their separation and nucleophilic substitution with morpholine, dimethylamine and hydrazine have been described. The lipophilicity of the azolopyridazines has been measured and rela
