66546-38-1

Upstream product

• 108835-27-4 8-(benzyloxy)quinoline-5-carboxaldehyde N-oxide 
• 100-44-7 benzyl chloride 
• 64028-40-6 8-benzyloxy-5-(1-hydroxy-2-isopropylamino-butyl)-1H-quinolin-2-one 
• 108835-26-3 8-(benzyloxy)-5-(hydroxymethyl)quinoline N-oxide 
• 108835-25-2 8-(benzyloxy)-5-(hydroxymethyl)quinoline 
• 4053-44-5 5-(hydroxymethyl)-8-hydroxyquinoline 
• 100-39-0 benzyl bromide 

Downstream Products

• 68304-21-2 8-hydroxy-2-oxo-1,2-dihydroquinoline-5-carbaldehyde 
• 128232-11-1 5-<2-<<1-(4-iodophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>-8-hydroxycarbostyril 
• 108835-37-6 5-<2-<<3-<4-(bromoacetamido)phenyl>-2-methylprop-2-yl>amino>-1-hydroxyethyl>-8-hydroxycarbostyril hydrobromide 
• 128232-10-0 8-(benzyloxy)-5-<2-<<1-(4-nitrophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>carbostyril 
• 128232-09-7 8-Benzyloxy-5-{1-hydroxy-2-[2-(4-iodo-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-1H-quinolin-2-one 
• 128232-08-6 8-(benzyloxy)-5-<2-<(1-phenyl-2-methylprop-2-yl)amino>-1-hydroxyethyl>carbostyril 
• 120551-46-4 5-{2-[2-(4-Amino-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-8-hydroxy-1H-quinolin-2-one 
• 67449-41-6 8-hydroxy-5-<2-<(1-phenyl-2-methylprop-2-yl)amino>-1-hydroxyethyl>carbostyril 
• 112281-28-4 8-benzyloxy-5-(epoxyethyl)-(1H)-quinolin-2-one 

Relevant academic research and scientific papers

Procaterol hydrochloride impurity preparation method

The invention discloses a procaterol hydrochloride impurity preparation method, which comprises: 1, adding procaterol hydrochloride to an organic solvent under an alkaline condition, adding an appropriate amount of benzyl halide, carrying out heating reflux until the reaction is complete, and carrying out post-treatment to obtain an intermediate 1; step 2, adding the intermediate 1 into a reaction bottle, then adding an organic solvent, raising the temperature, adding an oxidant aqueous solution, pouring into ice water after heating reaction is completed, and separating out a solid to obtain an intermediate 2; and step 3, adding the intermediate 2 into a reaction bottle, then adding an organic solvent, cooling to a low temperature, slowly adding boron trichloride, keeping the low temperature until the reaction is complete, pouring into ice water, separating out solids, and filtering to obtain the procaterol impurity. Procaterol hydrochloride which is easy to obtain is used as an initial raw material to prepare the procaterol hydrochloride impurity, the synthesis cost of the procaterol hydrochloride impurity is reduced, the preparation steps of the procaterol hydrochloride impurity are simplified, and the selectivity is improved, so that the preparation time is saved, and the preparation efficiency is improved. The total yield of the reaction is 50-70%.

BETA-AGONIST CARBOSTYRIL DERIVATIVES, ASSAY METHOD AND PHARMACOLOGICAL COMPOSITION

Beta-agonist carbostyril derivatives having the formula STR1 wherein X may be the ortho, meta or para position and is selected from the group consisting of halogen, amino and substituted and unsubstituted lower alkanoylamino having from 1 to 6 carbon atom

Carbostyril Derivatives Having Potent β-Adrenergic Agonist Properties

Derivatives carrying a substituent in the para position of the phenyl group of 8-hydroxy-5--1-hydroxyethyl>carbostyril (10) were prepared and their effects on β-adrenoceptors evaluated in vitro.Unsubstituted compound