66548-69-4 Usage
Uses
Used in Pharmaceutical Research:
CL 218872 is used as a research chemical for studying the effects and mechanisms of benzodiazepine receptor partial agonists. Its role in modulating the activity of the central nervous system makes it a significant compound for understanding the treatment of anxiety disorders and other related conditions.
Used in Anxiety Treatment:
CL 218872 is used as a putative anxiolytic for the potential treatment of anxiety disorders. As a BZR partial agonist, it may help alleviate anxiety symptoms by binding to benzodiazepine receptors and modulating the nervous system's response to stress and anxiety.
Used in Drug Development:
In the drug development industry, CL 218872 serves as a lead compound for the design and synthesis of new anxiolytic medications. Its unique properties as a partial agonist can inspire the creation of more effective and safer treatments for anxiety-related disorders.
Biological Activity
Benzodiazepine agonist displaying selectivity for α 1 subunit-containing GABA A receptors (K i values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α 1, α 2, α 3, α 4, α 5 and α 6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 66548-69-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,5,4 and 8 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 66548-69:
(7*6)+(6*6)+(5*5)+(4*4)+(3*8)+(2*6)+(1*9)=164
164 % 10 = 4
So 66548-69-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3
66548-69-4Relevant academic research and scientific papers
A New and Improved Synthesis of 6-Aryl-1,2,4-triazolopyridazines
Lieberman, Daniel F.,Albright, J. Donald
, p. 827 - 830 (2007/10/02)
A new and improved synthesis of 6-aryl-1,2,4-triazolopyridazines is described.This methodology provides the title compounds under mild conditions and in high yields.The first step comprises the condensation of an aryl methyl ketone with a 4-amino-1
Synthesis and Anxiolytic Activity of 6-(Substituted-phenyl)-1,2,4-triazolopyridazines
Albright, J. D.,Moran, D. B.,Wright, W. B.,Collins, J. B.,Beer, B.,et al.
, p. 592 - 600 (2007/10/02)
The synthesis of a series of 6-(substituted-phenyl)-1,2,4-triazolopyridazines (VIII) is reported.Some of these derivatives show activity in tests predictive of anxiolytic activity (a) protection against pentylenetetrazole-induced convulsions; (b)
Method for treating anxiety in mammals
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, (2008/06/13)
This disclosure describes compositions of matter useful as anxiolytic agents and the method of meliorating anxiety in mammals therewith; the active ingredients of said compositions of matter being certain substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines or the pharmacologically acceptable acid-addition salts thereof.
6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents
-
, (2008/06/13)
This disclosure describes novel substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines useful as hypotensive agents.
