66548-69-4 Usage
Uses
Different sources of media describe the Uses of 66548-69-4 differently. You can refer to the following data:
1. CL 218872 is a useful research chemical. CL 218872 is a putative anxiolytic.
2. CL 218872 is a benzodiazepine receptor (BZR) partial agonist and a putative anxiolytic.
Biological Activity
Benzodiazepine agonist displaying selectivity for α 1 subunit-containing GABA A receptors (K i values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α 1, α 2, α 3, α 4, α 5 and α 6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 66548-69-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,5,4 and 8 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 66548-69:
(7*6)+(6*6)+(5*5)+(4*4)+(3*8)+(2*6)+(1*9)=164
164 % 10 = 4
So 66548-69-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3
66548-69-4Relevant articles and documents
A New and Improved Synthesis of 6-Aryl-1,2,4-triazolopyridazines
Lieberman, Daniel F.,Albright, J. Donald
, p. 827 - 830 (2007/10/02)
A new and improved synthesis of 6-aryl-1,2,4-triazolopyridazines is described.This methodology provides the title compounds under mild conditions and in high yields.The first step comprises the condensation of an aryl methyl ketone with a 4-amino-1
Method for treating anxiety in mammals
-
, (2008/06/13)
This disclosure describes compositions of matter useful as anxiolytic agents and the method of meliorating anxiety in mammals therewith; the active ingredients of said compositions of matter being certain substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines or the pharmacologically acceptable acid-addition salts thereof.
