66553-15-9

Usage

Uses

Used in Chemical Reactions as a Solvent:
2,3-dimethylbutane-1,2-diol is used as a solvent in various chemical reactions for its ability to dissolve a wide range of substances, facilitating the progress of these reactions.
Used in Pharmaceutical Production:
2,3-dimethylbutane-1,2-diol is used as a key component in the production of pharmaceuticals, contributing to the synthesis of medicinal compounds due to its chemical reactivity and stability.
Used in Organic Compounds Synthesis:
2,3-dimethylbutane-1,2-diol is used as a building block for the synthesis of other organic compounds, serving as an important intermediate in organic chemistry, which allows for the creation of a diverse array of chemical products.
Used in Environmental Applications:
2,3-dimethylbutane-1,2-diol is considered to be relatively low in toxicity and is not known to be harmful to the environment, making it a preferred choice in applications where environmental impact is a concern.

InChI:InChI=1/C6H14O2/c1-5(2)6(3,8)4-7/h5,7-8H,4H2,1-3H3

Upstream product

• 98560-72-6 2-hydroxy-2,3-dimethyl-butyric acid ethyl ester 
• 563-78-0 2,3-Dimethyl-1-butene 
• 64-17-5 ethanol 
• 129257-01-8 2,3-dimethyl-but-3-ene-1,2-diol 
• 5396-58-7 2-methyl-2,3-butanediol 
• 4111-10-8 (+/-)-2-hydroxy-2,3-dimethylbutanenitrile 
• 594-52-5 2-bromo-2,3-dimethylbutane 
• 66461-67-4 2-hydroxy-2,3-dimethyl-butyric acid amide 
• 563-80-4 3-methyl-butan-2-one 
• 3639-20-1 (+/-)-2-hydroxy-2,3-dimethylbutanoic acid 

Downstream Products

• 132561-72-9 2,3-Dimethyl-1-(tosyloxy)-2-butanediol 
• 49642-48-0 2,3-dimethylbutanal 
• 743477-22-7 1-hydroxymethyl-1,2-dimethylpropyl ethylcarbamate 

Relevant academic research and scientific papers

A facile synthesis of vicinal cis-diols from olefins catalyzed by in situ generated MnxOy nanoaggregates

A novel protocol for the practical and green synthesis of vicinal cis-diols from 10.0 mmol olefins by using 5.0 mmol KMnO4 as oxidant and 30.0 mmol H2O2 as co-oxidant is reported. The presented procedure is easy to carry out and enables the direct transformation of linear and cyclic alkenes to the corresponding vicinal cis-diols. The synthesis of vicinal cis-diols by dihydroxylation of olefins with a KMnO4/H2O2 system was catalyzed by in situ generated MnxOy nanoaggregates. The use of H2O2 as a co-oxidant is the key for the protocol to synthesize vicinal cis-diols in high yields, because it assists the oxidation of MnxOy nanoaggregates, which have an active role in the oxidation reaction medium.

Kinetic resolution of 1,2-diols through highly site- and enantioselective catalytic silylation

(Chemical Equation Presented) Resolved to silylate: A chiral silylation catalyst is used for kinetic resolution of three classes of acyclic 1,2-diols. The catalyst differentiates, with excellent precision, between the two hydroxy groups of a substrate. The majority of the diols, obtained in high enantiomeric purity, cannot be accessed with similar stereochemical purity through catalytic asymmetric dihydroxylation.

Rh-catalyzed enantioselective diboration of simple alkenes: Reaction development and substrate scope

The rhodium-catalyzed reaction between bis(catecholato)diboron and simple alkenes results in the syn addition of the diboron across the alkene. The resulting 1,2-bis(boronate) is subsequently oxidized to provide the 1,2-diol. In the presence of enantiomerically enriched Quinap ligand, high enantioselection in the diboration can be achieved. The reaction is highly selective for trans- and trisubstituted alkenes and can be selective for some monosubstituted alkenes as well. The development of this reaction is described as is the substrate scope and experiments that are informative about the reaction mechanism and competing pathways.

DERMATOLOGICAL COMPOSITIONS AND METHODS

Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.

Treatment of neurodegenerative diseases

Disclosed are methods for increasing the differentiation of mammalian neuronal cells for purposes of treating neurodegenerative diseases or nerve damage by administration of various compounds including alcohols, diols and/or triols and their analogues.

Treatment of diseases mediated by the nitric oxide/cGMP/protein kinase G pathway

Disclosed are methods and compositions for stimulating cellular nitric oxide (NO) synthesis, cyclic guanosine monophosphate levels (cGMP), and protein kinase G (PKG) activity for purposes of treating diseases mediated by deficiencies in the NO/cGMP/PKG signal transduction pathway, by administration of various compounds including alcohols, diols and/or triols and their analogues.