5396-58-7

Basic information

• Product Name: 2-methylbutane-2,3-diol
• Synonyms: 2-methylbutane-2,3-diol;2-methyl-2,3-butanediol
• CAS NO: 5396-58-7
• Molecular Formula: C₅H₁₂O₂
• Molecular Weight: 104.14758
• EINECS: 226-414-3
• Mol File: 5396-58-7.mol
• Article Data: 17

Chemical Properties

• Melting Point: 50.86°C (estimate)
• Boiling Point: 209.24°C (rough estimate)
• Flash Point: 70.2°C
• Appearance: /
• Density: 0.9690
• Vapor Pressure: 0.362mmHg at 25°C
• Refractive Index: 1.4370
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.04±0.29(Predicted)
• CAS DataBase Reference: 2-methylbutane-2,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylbutane-2,3-diol(5396-58-7)
• EPA Substance Registry System: 2-methylbutane-2,3-diol(5396-58-7)

Safety Data

• Hazardous Substances Data: 5396-58-7(Hazardous Substances Data)

Usage

General Description

2-Methylbutane-2,3-diol is a chemical compound with the formula C5H12O2. It is a colorless, odorless liquid with a slightly sweet taste. 2-methylbutane-2,3-diol is commonly used in the production of pharmaceuticals, as well as in the manufacturing of fragrances and flavorings. It is also used as a solvent and as a component in antifreeze and de-icing solutions. 2-Methylbutane-2,3-diol is considered to be relatively non-toxic and is generally recognized as safe for use in food and cosmetic products. It is important to handle this compound with caution, however, as it is flammable and should be stored and used in a well-ventilated area.

InChI:InChI=1/C5H12O2/c1-4(6)5(2,3)7/h4,6-7H,1-3H3

Upstream product

• 5076-19-7 trimethyloxirane 
• 917-64-6 methyl magnesium iodide 
• 97-64-3 ethyl 2-hydroxypropionate 
• 513-35-9 2-methyl-but-2-ene 
• 115-22-0 3-Hydroxy-3-methyl-2-butanone 
• 21326-62-5 3-chloro-2-methyl-butan-2-ol 
• 594-51-4 2,3-dibromo-2-methylbutane 
• 64-17-5 ethanol 
• 67-64-1 acetone 
• 10473-14-0 3-methyl-3-buten-2-ol 
• 54697-76-6 4-(3,5-dinitro-benzoyloxy)-3,3-dimethyl-pentan-2-one 
• 63846-76-4 ethyl 2,4,6-tri-isopropylbenzoate 
• 68027-59-8 3-Hydroxy-3-methyl-but-2-yl-(2,4,6-triisopropylbenzoat) 
• 7664-93-9 sulfuric acid 

Downstream Products

• 563-80-4 3-methyl-butan-2-one 
• 594-61-6 2-methyllactic acid 
• 94972-51-7 4,4,5-trimethyl-2-phenyl-[1,3,2]dioxaborolane 
• 49642-48-0 2,3-dimethylbutanal 
• 66553-15-9 2,3-Dimethyl-1,2-Butanediol 
• 4111-10-8 (+/-)-2-hydroxy-2,3-dimethylbutanenitrile 
• 78-84-2 isobutyraldehyde 
• 26939-18-4 2,4,4,6-tetramethyl-5,6-dihydro-4H-1,3-oxazine 
• 630-19-3 pivalaldehyde 
• 7732-18-5 water 
• 81455-03-0 1,1-dimethyl-2-phenoxypropanol 
• 118831-85-9 4,4,5-trimethyl-2,2,2-triphenyl-1,3,2λ⁵-dioxaphospholane 
• 791-28-6 Triphenylphosphine oxide 
• 22931-96-0 4-Nitro-benzoic acid 2-hydroxy-1,2-dimethyl-propyl ester 

Relevant articles and documents

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Mo–Catalyzed One-Pot Synthesis of N-Polyheterocycles from Nitroarenes and Glycols with Recycling of the Waste Reduction Byproduct. Substituent-Tuned Photophysical Properties

A catalytic domino reduction–imine formation–intramolecular cyclization–oxidation for the general synthesis of a wide variety of biologically relevant N-polyheterocycles, such as quinoxaline- and quinoline-fused derivatives, and phenanthridines, is reported. A simple, easily available, and environmentally friendly dioxomolybdenum(VI) complex has proven to be a highly efficient and versatile catalyst for transforming a broad range of starting nitroarenes involving several redox processes. Not only is this a sustainable, step-economical as well as air- and moisture-tolerant method, but also it is worth highlighting that the waste byproduct generated in the first step of the sequence is recycled and incorporated in the final target molecule, improving the overall synthetic efficiency. Moreover, selected indoloquinoxalines have been photophysically characterized in cyclohexane and toluene with exceptional fluorescence quantum yields above 0.7 for the alkyl derivatives.

Polymer-mediated pinacol rearrangements

Both poly(3,4-ethylenedioxythiophene) and poly(pyrrole) mediate a pinacol rearrangement of 1,2-diols. The yields of ketone or aldehyde products are comparable to those observed for treatment with mineral acids or Lewis acids. The advantage of this protocol is a two-phase reaction medium in hydrocarbon solvents that allows facile recovery of the products by simple filtration of the polymer and removal of solvents. Both the polymer and the hydrocarbon solvent may be recovered and used in subsequent reactions. Georg Thieme Verlag Stuttgart · New York.

THIENOPYRIMIDINES CONTAINING A SUBSTITUTED ALKYL GROUP FOR PHARMACEUTICAL COMPOSITIONS

The present invention relates to novel thienopyrimidine compounds of general formula pharmaceutical compositions comprising these compounds and their therapeutic use for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.