66581-99-5

Upstream product

• 30787-43-0 5'-(chloromethyl)-2'-hydroxyacetophenone 
• 151-50-8 potassium cyanide 
• 67741-16-6 O-acetyl-4-hydroxyphenylacetonitrile 
• 773837-37-9 sodium cyanide 
• 14191-95-8 4-cyanomethylphenol 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 101451-72-3 (4-oxo-2-phenyl-chroman-6-yl)-acetic acid 
• 107275-23-0 [4-hydroxy-3-(4-hydroxy-trans-cinnamoyl)-phenyl]-acetic acid 
• 101451-67-6 (3-trans-cinnamoyl-4-hydroxy-phenyl)-acetic acid 
• 102-32-9 3,4-dihydroxyphenylacetate 
• 99059-05-9 2-(3-acetyl-4-hydroxyphenyl)acetic acid 
• 1126-62-1 (3,4-dihydroxy-phenyl)-acetonitrile 

Relevant academic research and scientific papers

Flavone acetic acid derivatives, pharmaceutical composition thereof as well as preparation methods and applications of flavone acetic acid derivatives and pharmaceutical composition

The invention belongs to the field of medication chemistry, and relates to flavone acetic acid derivatives, pharmaceutical composition thereof as well as preparation methods and applications of the flavone acetic acid derivatives and the pharmaceutical co

One-step Synthesis of N1-(1-Benzylisoquinolin-3-yl)phenylacetamidinium Trifluoromethanesulphonate Derivatives from Phenylacetonitriles and Trifluoromethanesulphonic Acid.

The phenylacetonitriles 3,4-R1R2C6H3CH2CN (R1, R2 = H, Me, Cl or F) and C6H5CH(c-C6H11)CN react with triflic acid under various conditions to give the corresponding N1-(1-benzylisoquinolin-3-yl)phenylacetamidinium triflate derivatives in moderate to high yields.This novel cyclotrimerization reaction can also be carried out with PhCH2CN using fluorosulphonic acid, and, in low yield, with HBF4/Et2O while ClSO3H, 4-MeC6H4SO3H and HCl/ZnCl2 give only phenylacetamide under similar conditions.Reaction of phenylacetonitrile with dry HCl resulted mainly in the formation of 1,3,5-tribenzyltriazine.Isoquinoline formation is not observed upon reaction or either 4-MeOC6H4CH2CN or 3,4-(MeO)2C6H3CH2CN with triflic acid, but complex product mixtures probably resulting from Houben-Hoesch reactions are obtained. 4-Acetoxyphenylacetonitrile gives a low yield of the Fries rearrangement product.