66584-29-0Relevant academic research and scientific papers
Preparation, physicochemical properties, and transfection activities of tartaric acid-based cationic lipids as effective nonviral gene delivery vectors
Wan, Ning,Jia, Yi-Yang,Hou, Yi-Lin,Ma, Xi-Xi,He, Yong-Sheng,Li, Chen,Zhou, Si-Yuan,Zhang, Bang-Le
, p. 1112 - 1120 (2016/07/19)
In this work two novel cationic lipids using natural tartaric acid as linking backbone were synthesized. These cationic lipids were simply constructed by tartaric acid backbone using head group 6-aminocaproic acid and saturated hydrocarbon chains dodecanol (T-C12-AH) or hexadecanol (T-C16-AH). The physicochemical properties, gel electrophoresis, transfection activities, and cytotoxicity of cationic liposomes were tested. The optimum formulation for T-C12-AH and T-C16-AH was at cationic lipid/dioleoylphosphatidylethanolamine (DOPE) molar ratio of 1:0.5 and 1:2, respectively, and N/P charge molar ratio of 1:1 and 1:1, respectively. Under optimized conditions, T-C12-AH and T-C16-AH showed effective gene transfection capabilities, superior or comparable to that of commercially available transfecting reagent 3β-[N-(N′,N′-dimethylaminoethyl)carbamoyl]cholesterol (DC-Chol) and N-[2,3-dioleoyloxypropyl]-N,N,N-trimethylammonium chloride (DOTAP). The results demonstrated that the two novel tartaric acid-based cationic lipids exhibited low toxicity and efficient transfection performance, offering an excellent prospect as nonviral vectors for gene delivery.
Dicarboxylic acid esters as transdermal permeation enhancers: Effects of chain number and geometric isomers
Novotny, Michal,Hrabalek, Alexandr,Janusova, Barbora,Novotny, Jakub,Vavrova, Katerina
supporting information; experimental part, p. 344 - 347 (2011/02/26)
A series of transdermal permeation enhancers based on dicarboxylic acid esters was studied. Single-chain amphiphiles were markedly more effective than the double-chain ones. Monododecyl maleate, that is a cis derivative, was a more potent enhancer than its trans isomer, while the activity of succinates strongly depended on the donor vehicle. No difference between diastereoisomeric tartaric and meso-tartaric acid derivatives was found.
Enantioselective distribution of amino-alcohols in a liquid-liquid two-phase system containing dialkyl L-tartrate and boric acid
Abe,Shoji,Kobayashi,Qing,Asai,Nishizawa
, p. 262 - 265 (2007/10/02)
Racemic amino-alcohols such as pindolol, propranolol, alprenolol and bucumolol enantiomers exhibited different distribution behaviors in a two-phase system consisting of a chloroform solution of didodecyl L-tartrate and an aqueous solution of boric acid. It seemed that a borate complex of the 1,2-diol group of the tartrate and the amino-alcohol was formed in the system. In the case of pindolol, one enantiomer was preferentially extracted into the organic phase (x 2.20) at equilibrium.
