66584-35-8

Basic information

• Product Name: tamoxifen hydrochloride
• CAS NO: 66584-35-8
• Molecular Weight: 407.983
• Mol File: 66584-35-8.mol

Chemical Properties

• CAS DataBase Reference: tamoxifen hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: tamoxifen hydrochloride(66584-35-8)
• EPA Substance Registry System: tamoxifen hydrochloride(66584-35-8)

Safety Data

• Hazardous Substances Data: 66584-35-8(Hazardous Substances Data)

Upstream product

• 622-76-4 1-phenyl-1-butyne 
• 93790-54-6 [2-(4-iodophenoxy)ethyl]dimethylamine 
• 113619-15-1 (Z)-1-iodo-1,2-diphenyl-1-butene 

Relevant articles and documents

A Nickel-catalyzed carbozincation of aryl-substituted alkynes

The addition of dialkylzincs or diphenylzinc to substituted phenylacetylenes in the presence of catalytic amounts of Ni(acac)2 in THF:NMP mixtures produces syn-carbozincation products with good to excellent regio- and stereoselectivity. After quenching with an electrophile (iodine, acyl chloride, allyl bromide) tetrasubstituted olefines are obtained in good to satisfactory yields. An intramolecular version of the reaction is possible using a terminal triple bond bearing an iodine at a remote position. More substituted iodo-alkynes furnish only reductive elimination products. An application to a stereoselective synthesis of (Z)-tamoxifen (Z:E > 99:1) has been developed.