66596-91-6

Upstream product

• 77440-84-7 dichloro-2,4 trimethoxy-1,3,5 benzene 
• 24605-25-2 3-chloro-2,6-dimethoxybenzoquinone 
• 2539-26-6 3,4,5-trichlorosyringol 
• 15233-65-5 2,6-dimethoxy-1,4-hydroquinone 
• 67-56-1 methanol 
• 118-75-2 chloranil 
• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 5333-45-9 1,2,3,5-tetramethoxybenzene 

Downstream Products

• 107774-19-6 2,6-dichloro-3-(trans-2-diethylamino-vinyl)-5-methoxy-[1,4]benzoquinone 
• 100127-26-2 2-butylamino-3,5-dichloro-6-methoxy-[1,4]benzoquinone 
• 101355-27-5 2,5-bis-butylamino-3-chloro-6-methoxy-[1,4]benzoquinone 
• 66596-97-2 7,9-dichloro-6,10-dimethoxy-3-(2,4,6-trimethyl-phenyl)-1,4-dioxa-2-aza-spiro[4.5]deca-2,6,9-trien-8-one 
• 66596-98-3 6,10-dichloro-7,9-dimethoxy-3-(2,4,6-trimethyl-phenyl)-1,4-dioxa-2-aza-spiro[4.5]deca-2,6,9-trien-8-one 

Relevant academic research and scientific papers

3,5-dichloro-2,6-dimethoxycyclohexa-2,5-diene-1,4-dione

A new synthesis of the title compound, C8H6Cl2O4, is described. The molecule has a mirror plane and the six-membered carbon ring assumes a slight boat conformation. The ring substituents are arranged in an alter

A Catalytic Oxidative Quinone Heterofunctionalization Method: Synthesis of Strongylophorine-26

The preparation of heteroatom-substituted p-quinones is ideally performed by direct addition of a nucleophile followed by in situ reoxidation. Albeit an appealing strategy, the reactivity of the p-quinone moiety is not easily tamed and no broadly applicable method for heteroatom functionalization exists. Shown herein is that Co(OAc)2 and Mn(OAc)3?2 H2O act as powerful catalysts for oxidative p-quinone functionalization with a collection of O, N, and S nucleophiles, using oxygen as the terminal oxidant. Preliminary mechanistic observations and the first synthesis of the cytotoxic natural product strongylophorine-26 is presented.