66612-94-0Relevant academic research and scientific papers
Ag(I)-Catalyzed Synthesis of Azabicyclic Alkaloid Frameworks from Ketimine-Tethered Ynones: Total Synthesis of Indolizidine 209D
Ho, Hon Eong,James, Michael J.,O'Brien, Peter,Taylor, Richard J. K.,Unsworth, William P.
, p. 1439 - 1443 (2018)
An efficient Ag(I)-catalyzed π-acid activation method for the cyclization of cyclic ketimine-tethered ynones is reported. Various nitrogen-containing scaffolds commonly found in bioactive alkaloids can be prepared in high yields, and the utility of the method is demonstrated by a formal synthesis of (±)-lasubine II and in a short total synthesis of (±)-indolizidine 209D.
