666234-81-7 Usage
General Description
(R)-3-(Dimethylamino)-1,2-propanediol, also known as Ropivacaine, is a local anesthetic medication used for pain management. It works by blocking the nerve signals in the body, leading to temporary numbness and relief from discomfort. Ropivacaine is commonly used during surgical procedures, epidural anesthesia for labor and delivery, and for post-operative pain control. It has a longer duration of action compared to other local anesthetics, making it an effective choice for prolonged pain relief. However, it is important to use ropivacaine under the supervision of a healthcare professional, as improper use can result in serious side effects and complications.
Check Digit Verification of cas no
The CAS Registry Mumber 666234-81-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,6,6,2,3 and 4 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 666234-81:
(8*6)+(7*6)+(6*6)+(5*2)+(4*3)+(3*4)+(2*8)+(1*1)=177
177 % 10 = 7
So 666234-81-7 is a valid CAS Registry Number.
666234-81-7Relevant articles and documents
Asymmetric Synthesis of Dialkyloxy-3-alkylammonium Cationic Lipids
Hurley, Christopher A.,Wong, John B.,Hailes, Helen C.,Tabor, Alethea B.
, p. 980 - 983 (2004)
The cationic diether-linked cytofectin DOTMA (available commercially as a mixture, Lipofectin comprised of DOTMA:DOPE, 1:1) and analogues including DIMRIE and DORIE are frequently used for in vitro and in vivo transfections. Despite this wide usage direct synthetic routes to the optical isomers have received little attention to date. Here we describe strategies to synthesize enantiomers of DOTMA and analogues, including an extremely concise procedure to the trimethylammonium salts. One strategy utilized N-protection, as the imine, with concomitant ether formation and deprotection during the workup. Methylation of the 1-amino-2,3-dialkyloxypropane then generated the trimethylammonium cationic lipids directly. This methodology was extended to synthesize a novel headgroup functionalized lipid. A second route was also developed using an alternative chiral synthon.
