66629-58-1Relevant academic research and scientific papers
An improved synthesis of 4-methylene-2-cyclohexen-1-one
Jung,Rayle
, p. 197 - 203 (1994)
An improved synthesis of 4-methylene-2-cyclohexen-1-one (1) is described, which involves four steps from commercially available starting materials and proceeds in 65-75% overall yield.
Straightforward synthesis of nonconjugated cyclohex-3-enone and conjugated 4-methylenecyclohex-2-enone derivatives
Kuttner, Julian R.,Warratz, Svenja,Hilt, Gerhard
experimental part, p. 1293 - 1303 (2012/06/30)
The synthesis of nonconjugated cyclohex-3-enones via the regiodivergent cobalt-catalysed Diels-Alder reactions of 2-(trimethylsilyloxy)buta-1,3-diene with alkynes and hydrolysis of the dihydroaromatic intermediates is described. The application of bidentate phosphine ligands versus pyridine-imine ligands led to the regioselective formation of one out of the two possible regioisomeric products when terminal or unsymmetrically substituted alkynes were applied. The cyclohex-3-enone products were isolated mostly in good yields without isomerisation of the carbon-carbon double bond into conjugation based on the mild reaction conditions. The use of acetoxymethyl-substituted alkynes led to the conjugated 4-methylenecyclohex-2-enones after deprotection of the silyl enol ether. Georg Thieme Verlag Stuttgart · New York.
Enantioselective total synthesis of the antifungal natural products chorotetaine, bacilysin, and anticapsin and of related compounds: Revision of the relative configuration
Wild
, p. 2748 - 2761 (2007/10/02)
Enantioselective and diastereoselective syntheses of the title antifungal natural products and some of their diastereoisomers are described. Key steps include the diastereoselective 1,6-addition of bislactim ether 14 and a stereoselective deprotonation of
