66630-74-8

Basic information

• Product Name: 4-amino-3-(methylamino)benzoic acid
• Synonyms: 4-amino-3-(methylamino)benzoic acid
• CAS NO: 66630-74-8
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.1772
• Mol File: 66630-74-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 392.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.343±0.06 g/cm3(Predicted)
• PKA: 3.81±0.10(Predicted)
• CAS DataBase Reference: 4-amino-3-(methylamino)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-3-(methylamino)benzoic acid(66630-74-8)
• EPA Substance Registry System: 4-amino-3-(methylamino)benzoic acid(66630-74-8)

Safety Data

• Hazardous Substances Data: 66630-74-8(Hazardous Substances Data)

Upstream product

• 5081-37-8 methyl 3-methoxy-4-nitrobenzoate 
• 619-14-7 3-hydroxy-4-nitro-benzoic acid 
• 5081-36-7 3-methoxy-4-nitrobenzoic acid 
• 214778-10-6 3-methylamino-4-nitro-benzoic acid 

Downstream Products

• 429658-95-7 3-({2-[(4-carbamimidoylphenylamino)methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}pyridin-2-yl-amino)propionic acid ethyl ester 
• 872728-85-3 1-methyl-2-[N-(4-amidino-phenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid N-(2-pyridyl)-N-2-(ethoxycarbonylethyl)-amide p-toluenesulfonic acid salt 
• 211915-06-9 dabigatran etexilate 
• 1331740-84-1 4-((1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)(1H-1,2,4-triazol-1-yl)methyl)phenyl sulfamate 
• 1331740-83-0 4-((1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)(1H-1,2,4-triazol-1-yl)methyl)phenol 
• 1331740-82-9 6-((4-benzyloxyphenyl)(1H-1,2,4-triazol-1-yl)methyl)-1-methyl-1H-benzo[d][1,2,3]triazole 
• 1331740-81-8 (4-benzyloxyphenyl)(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)methanol 
• 114408-87-6 1-methyl-1H-benzotriazole-6-carboxaldehyde 
• 1038387-93-7 methyl 1,2-dimethyl-1H-benzimidazole-6-carboxylate 
• 214782-14-6 2-[1-(5-benzyloxycarbonyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)ethyl]-3-methyl-3H-benzoimidazole-5-carboxylic acid 

Relevant articles and documents

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Development summary towards a manufacturable process for R 83842 [(S)-6-[(4-chlorophenyl) (1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole]

A scalable process to produce enantiomeric R 83842, (S)-6-[(4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole, is developed and described as a lecture * transcript. Cheap and safe reagents have been used. A typical procedure for oxidative destruction of aqueous cyanide waste, and stability data on N-acetyl hydrazine are provided. Special focus is on cost analysis as an important tool in developing performant synthetic methods. The method consists of preparing a chiral monosubstituted hydrazine which is ring closed to the chiral 1-alkylated 1,2,4-triazole title compound.