66636-17-7

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 619-05-6 3,4-diaminobenzoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant academic research and scientific papers

Evaluation of new benzimidazole derivatives as cysticidal agents: In vitro, in vivo and docking studies

Based on our previous research on cysticidal drugs, we report the synthesis and evaluation of three new benzimidazole derivatives. In these compounds, the amido group was used as a bioisosteric replacement of the ester group. The molecular docking on β-tu

LINKER-DRUG AND ANTIBODY-DRUG CONJUGATE (ADC) EMPLOYING THE SAME

A linker-drug represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), C is a conjugator, L is a linker unit, D is a toxin unit, and n is an integer ranging from 1 to 4. The structure of the conjugator is represented by formula (II). In formula (II), X is a leaving group, each of R1 and R2 is independently a single bond or —NH—, and Z is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or a combination thereof. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. An antibody-drug conjugate (ADC) employing the above linker-drug is also provided.

Removable saccharide-benzimidazole (BIM) tags and conjugates thereof via 1H-position of the benzimidazoles

Novel method and reagents for generating reversibly tagged saccharides, aldehydes, carboxyl acids, or orthoacetates useful in analytical and diagnostic applications are disclosed. Saccharides are coupled at the reducing end to tagging moieties comprising

Mitochondria-targeting oxidovanadium(IV) complex as a near-ir light photocytotoxic agent

Oxidovanadium(IV) complexes [VO(L1)(phen)]×Cl (1) and [VO(L2)(L3)]×Cl (2), in which HL1 is 2-{[(benzimidazol-2-yl)methylimino]-methyl}phenol (sal-ambmz), HL2 is 2-[({1-[(anthracen-9-yl)methyl]-benzimi

An efficient and highly chemoselective N-Boc protection of amines, amino acids, and peptides under heterogeneous conditions

A simple and efficient procedure for chemoselective mono-N-Boc protection of various structurally diverse amines, amino acids, and peptides with di-tert-butyl dicarbonate using Amberlyst-15 as catalyst in ethanol is described. The catalyst can be readily separated from the reaction products with simple filtration and recovered for direct reuse. No competitive side-reactions such as formation of isocyanate, urea, oxazolidinone, and N,N-di-Boc derivatives were observed.

Guanidine hydrochloride as an organocatalyst for N-Boc protection of amino groups

A simple and efficient method for the chemoselective N-Boc protection of the amine moiety in a variety of compounds is described using di-tert-butyl dicarbonate and guanidine hydrochloride as an organocatalyst in ethanol at 35-40°C. Selective mono-N-Boc protection of diamines and chemoselective protection of hydroxylamines without formation of any side products is achieved. Amino acids and peptides are N-Boc protected efficiently in excellent yields under convenient reaction conditions.

Electrochemiluminescent peptide nucleic acid-like monomers containing Ru(II)-dipyridoquinoxaline and Ru(II)-dipyridophenazine complexes

A series of Ru(II)-peptide nucleic acid (PNA)-like monomers, [Ru(bpy) 2(dpq-L-PNA-OH)]2+ (M1), [Ru(phen)2(dpq-L-PNA- OH)]2+ (M2), [Ru(bpy)2(dppz-L-PNA-OH)]2+ (M3), and [Ru(phen)2

New conjugates of β-cyclodextrin with manganese(iii) salophen and porphyrin complexes as antioxidant systems

Oxidative stress is the hallmark of several pathologies like arthritis, hypertension and many neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. In this scenario, antioxidant compounds can play a pivotal role in treating these severe pathologies. The synthesis of molecules able to mimic physiologically-relevant proteins is nowadays of particular interest. Several transition metal complexes, especially manganese(iii) complexes with porphyrin and salen-type ligands, have been reported to be superoxide scavengers. Here we report the synthesis and spectroscopic characterization of manganese(iii) complexes of 5[4-(6-O-β-cyclodextrin)-phenyl],10,15,20- tri(4-hydroxyphenyl)-porphyrin and of 6A-deoxy-6A[(S- cysteamidobenzoyl(3,4-diamino)-N,N′-bis(salicylidene))] -β-cyclodextrin. The superoxide dismutase activity of the metal complexes was investigated by indirect methods. The catalase and peroxidase activities were tested using ABTS assays. The Royal Society of Chemistry 2011.

BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE

Disclosed are compounds, compositions and methods for treatingFlaviviridae family virus infections.

Melanoma uptake of 99mTc complexes containing the N-(2-diethylaminoethyl)benzamide structural element

On the basis of the avid uptake of radioiodinated benzamides by melanoma cells, 99mTc complexes containing the structural elements of N-(dialkylaminoalkyl)benzamide pharmacophores have been synthesized and evaluated in vitro and in vivo for mel