DI-BOC-3,4-DIAMINOBENZOIC ACID

Base Information

• Chemical Name: DI-BOC-3,4-DIAMINOBENZOIC ACID
• CAS No.: 66636-17-7
• Molecular Formula: C17H24N2O6
• Molecular Weight: 352.387
• Hs Code.: 2924299090

Synonyms:3,4-bis-tert-butoxycarbonylaminobenzoic acid;N,N'-di-Boc-3,4-diaminobenzoic acid;

Chemical Property of DI-BOC-3,4-DIAMINOBENZOIC ACID

Chemical Property:

• PSA: 120.94000
• LogP: 4.10600

Purity/Quality:

98%min ^*data from raw suppliers

Di-Boc-3,4-diaminobenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DI-BOC-3,4-DIAMINOBENZOIC ACID

There total 2 articles about DI-BOC-3,4-DIAMINOBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + 3,4-diaminobenzoic acid (619-05-6) → N,N'-di-(tert-butoxycarbonyl)-3,4-diaminobenzoic acid (66636-17-7)

Guidance literature:

With amberlyst-15; In ethanol; at 20 ℃; for 4.5h; chemoselective reaction;

DOI:10.1007/s00706-011-0534-2

Reference yield:

N-(tert-butyloxycarbonyl) azide (1070-19-5) + 3,4-diaminobenzoic acid (619-05-6) → N,N'-di-(tert-butoxycarbonyl)-3,4-diaminobenzoic acid (66636-17-7)

Guidance literature:

With triethylamine; In 1,4-dioxane; water;

Reference yield: 87.0%

methyl 4-(aminomethyl)benzoate (18469-52-8) + N,N'-di-(tert-butoxycarbonyl)-3,4-diaminobenzoic acid (66636-17-7) → methyl 4-[(3,4-bis{tert-butoxycarbonylamino}benzamido)methyl]benzoate

Guidance literature:

N,N'-di-(tert-butoxycarbonyl)-3,4-diaminobenzoic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; at 60 ℃; for 8h;

methyl 4-(aminomethyl)benzoate; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 24h;

DOI:10.1248/cpb.c19-00574

upstream raw materials:

di-tert-butyl dicarbonate

3,4-diaminobenzoic acid

N-(tert-butyloxycarbonyl) azide

Downstream raw materials:

[2-tert-Butoxycarbonylamino-4-(2-diethylamino-ethylcarbamoyl)-phenyl]-carbamic acid tert-butyl ester

4-[2-(N,N-diethylamino) ethylamino-carbonyl]-o-phenylene diamine

3,4-bis-tert-butoxycarbonylamino-benzoic acid (5-chloro-pyridine-2-yl)amide

ethyl 6-(3,4-bis(tert-butoxycarbonylamino)benzamido)hexanoate

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