66643-80-9

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 82353-56-8 (2R)-2-N-t-butoxycarbonyl-aminopropanal 
• 15761-38-3 L-N-Boc-Ala 
• 35116-15-5 Dibasic magnesium salt of ethyl hydrogen malonate 
• 125814-30-4 BOC-L-alanine-NCA 
• 141-78-6 ethyl acetate 
• 79069-50-4 Boc-Ala-H 
• 146553-06-2 tert-butyl {(S)-1-[methoxy(methyl)amino]-1-oxopropan-2-yl}carbamate 
• 1071-46-1 hydrogen ethyl malonate 
• 79069-13-9 (S)-2-t-butoxycarbonylaminopropan-1-ol 
• 54430-64-7 [(1S)-2-imidazol-1-yl-1-methyl-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 79069-13-9 (R)-2-tertbutoxycarbonylamino-1-propanol 
• 3744-87-4 Boc-(R)-Ala 
• 147252-84-4 tert-butyl (1-hydroxypropan-2-yl)carbamate 

Relevant academic research and scientific papers

Synthesis of tetrasubstituted symmetrical pyrazines from β-keto γ-amino esters: A mild strategy for self-dimerization of peptides

A facile synthesis of highly symmetrical tetrasubstituted pyrazines through simple aerial oxidation of β-keto γ-amino esters is reported. The scope of the reaction was examined by use of various amino acid side-chain functional groups andpeptides. The mil

HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorde

A facile transformation of amino acids to functionalized coumarins

The synthesis of novel chiral coumarins functionalized with proteinogenic amino acid side chains via N-protected γ-amino-β-keto esters and their incorporation into the cell permeable HIV-1 TAT peptide through the modified solid phase peptide synthesis are

Tin(ii) chloride assisted synthesis of N-protected γ-amino β-keto esters through semipinacol rearrangement

A facile synthetic route for the preparation of N-protected γ-amino β-keto esters from amino aldehydes and ethyl diazoacetate is described. The two component coupling is facilitated by tin(ii) chloride followed by semipinacol rearrangement leading to the product in quantitative yield. The reaction is mild, instantaneous and compatible with Boc-, Fmoc- and Cbz-amino protecting groups.

Synthesis of N-protected γ-amino-β-keto-esters from urethane N-carboxyanhydrides (UNCAs)

N-protected γ-amino-β-keto-esters were synthesized from the corresponding N-protected N-carboxyanhydride (UNCAs) by reaction with the lithium enolate of ethyl acetate in good yields. These compounds are precursors of statine derivatives.

Synthesis and structure-activity relationships of 7-[3-(1- aminoalkyl)pyrrolidinyl]- and 7-[3-1-aminocycloalkyl)pyrrolidinyl]-quinolone antibacterials

A series of 7-[3-(1-aminoalkyl and 1-aminocycloalkyl)-1- pyrrolidinyl]quinolones have been prepared and their biological properties evaluated. Among them, 1-(S)-aminoalkyl derivatives exhibited potent antibacterial activities against gram-positive and gram-negative organisms. They had moderate lipophilicity and high aqueous solubility compared to their aminomethyl counterparts; e.g., the 3-(1-aminoethyl)-1-pyrrolidinyl compound (83) showed superior pharmacokinetic properties to its aminomethyl counterpart (6).

Syntheses and structure-activity studies of analogues and γ-aminobutyric acid (GABA)

The syntheses of (2RS,4RS)- and (2RS,4SR)-2-hydroxy-4-aminopentanoic acid, (3RS,4R)- and (3RS,4S)-3-hydroxy-4-aminopentanoic acid, (RS)-3-hydroxy-5-aminopentanoic acid, trans-(R)- and trans-(S)-4-amino-2-pentenoic acid and trans-5-amino-2-pentenoic acid are described. The compounds were tested as inhibitors of the binding of 3H-GABA to receptor sites on membranes from rat brains and some of the compounds were tested as inhibitors of the >-uptake to GABA into rat brain slices.