66644-79-9

Usage

Uses

Used in Pharmaceutical Research:
2-BROMO-4-METHYLPHENYLTHIOUREA is used as a research compound for the development of new pharmaceuticals and bioactive compounds. Its versatile structure makes it a promising building block for creating novel therapeutic agents.
Used in Organic Synthesis:
2-BROMO-4-METHYLPHENYLTHIOUREA is used as a reagent in the synthesis of various organic compounds, contributing to the development of new chemical entities with potential applications in various industries.
Used in Thyroid Disorder Treatment:
2-BROMO-4-METHYLPHENYLTHIOUREA has been studied for its potential use in the treatment of thyroid disorders, indicating its possible application in the medical field for managing such conditions.
Used in Cancer Treatment Research:
2-BROMO-4-METHYLPHENYLTHIOUREA has been investigated for its potential role in cancer treatment, suggesting that it could be utilized in oncology research to develop new cancer therapies.

Upstream product

• 19241-39-5 (2-bromo-4-methylphenyl)isothiocyanate 
• 13194-71-3 2-bromo-4-methyl-aniline; hydrochloride 
• 58655-25-7 C₆H₁₅N*C₈H₈BrNS₂ 
• 583-68-6 2-bromo-p-toluidine 
• 446831-64-7 1-benzoyl-3-(2-bromo-4-methyl-phenyl)-thiourea 

Downstream Products

• 109317-47-7 2-(2-Bromo-4-methyl-phenylamino)-5,5-dimethyl-5,6-dihydro-4H-benzothiazol-7-one; hydrobromide 
• 109317-29-5 (2-Bromo-4-methyl-phenyl)-(4,5,6,7-tetrahydro-benzothiazol-2-yl)-amine 
• 1208070-80-7 2-bromo-4-methylphenylcyanamide 
• 1201683-18-2 2-(4-nitrophenylthio)-4-methylphenylcyanamide 
• 1201683-11-5 4-methyl-2-(phenylthio)phenylcyanamide 
• 1201683-27-3 2-(4-methylphenylthio)-4-methylphenylcyanamide 
• 1260248-77-8 2-(2-nitrophenylthio)-4-methylphenylcyanamide 
• 85063-58-7 6-methyl-N-(2-nitrophenyl)benzo[d]thiazol-2-amine 
• 1201683-15-9 2-(4-aminophenylthio)-4-methylphenylcyanamide 

Relevant academic research and scientific papers

Environmentally benign one-pot synthesis of cyanamides from dithiocarbamates using I2 and H2O2

An environmentally benign reaction is devised for the synthesis of cyanamides from dithiocarbamate salts using iodine and H2O 2. Taylor & Francis Group, LLC.

A one-pot preparation of cyanamide from dithiocarbamate using molecular iodine

An efficient one-pot method for the synthesis of cyanamides from dithiocarbamate salts via a double desulfurization strategy using molecular iodine is disclosed. Dithiocarbamates, by the action of iodine yield isothiocyanates in situ, which on treatment with aqueous NH3 give thioureas. The thioureas so generated undergo further oxidative desulfurization with I2 giving corresponding cyanamides in good yields. Environmental benignity, cost effectiveness and high yields are the important attributes of this one pot procedure. The Royal Society of Chemistry 2009.

Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents

A series of arylthioureas (1), aromatic aldehyde thiosemicarbazones (2) and 5-aryl-2-furfuraldehyde thiosemicarbazones (3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles (4). The newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies. These compounds were also screened for their antibacterial and anti-inflammatory activities. Two of the newly synthesized compounds showed anti-inflammatory activity comparable with that of Ibuprofen.

Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors

The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino-1,3-thiazolyl]-thiophene-2-carboxamidines is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities.