66659-96-9

Upstream product

• 3141-93-3 4',5'-dimethoxydeoxybenzoin 
• 103-80-0 phenylacetyl chloride 
• 91-16-7 1,2-dimethoxybenzene 

Downstream Products

• 239448-50-1 4-(3,4-dimethoxyphenyl)-2-methyl-5-phenylthiazole 
• 919519-13-4 1-(3,4-dimethoxyphenyl)-1-hydroxy-3-methyl-2-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 919519-04-3 3,4-dimethoxy-N-[2-(2-iodophenyl)ethyl]-N-methyl-α-phenylphenacylamine 
• 78643-32-0 6-(3,4-dimethoxy-phenyl)-5-phenyl-2,3-dihydro-imidazo[2,1-b]thiazole 
• 5782-34-3 2-(3,4-dimethoxy-phenyl)-3-phenyl-indole 

Relevant academic research and scientific papers

Synthesis of new 1,2-Diphenyl-4, 5-dihydro-3H-3-benzazepines

1,2-Diphenyl-4,5-dihydro-3H-3-benzazepine derivatives (2a-d) were synthesized via cyclization reaction of N-[2-(2-iodophenyl)ethyl]-α-phenylphenacylamines (5a-c) and (5e) with n-C4H9Li, followed by dehydration of the cyclization prod

A simple route to new phenanthro- and phenanthroid-fused thiazoles by a PIFA-mediated (hetero)biaryl coupling reaction

An application of the PIFA-mediated [PIFA: phenyliodine(III) bis(trifluoroacetate) biaryl coupling reaction is presented and extended to the formation of heterobiaryl connections. A preliminary study of the scope and limitations of this procedure was carried out in the synthesis of phenanthroids 11 from a series of phenethyl-substituted heterocycles 10, It was observed that in some cases a competitive dimerization process took place. It was also found that the coupling step could be efficiently extended to a larger number of examples if an aromatic ring were situated fused to the 1,2-diarylethane skeleton, as in 23 and 30. The synthesis of a series of 4,5-diarylthiazoles 23a-g was therefore carried out to explore the electronic requirements and the regioselectivity of the PIFA-mediated non-phenolic coupling reaction. When the same procedure was applied to aryl-heteroarylthiazoles 30, a series of phenanthroid-fused thiazoles 31 was obtained in good overall yields. To the best of our knowledge, no oxidative aryl-heteroaryl coupling reaction of this type had previously been reported. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.