66670-33-5Relevant academic research and scientific papers
Chlorophyll-catalyzed photochemical regioselective coumarin C-H arylation with diazonium salts
Moazzam, Ali,Jafarpour, Farnaz
, p. 16692 - 16696 (2020)
This communication describes the development of a mild method for the cross-coupling of the C3-position of coumarin with an array of diazonium salts mediated by chlorophyll as a biocatalyst via visible light catalysis. A natural pigment such as chlorophyll is used as a green photosensitizer and environmentally benign catalyst. This general and easy procedure provides a transition-metal-free alternative for the formation of 3-aryl coumarin derivatives at room temperature with good to excellent yields. This journal is
Synthesis and biological evaluation of resveratrol-coumarin hybrid compounds as potential antitumor agents
Shen, Wei,Mao, Jianfeng,Sun, Juan,Sun, Minjie,Zhang, Can
, p. 1630 - 1640 (2013/07/26)
Eighteen resveratrol-coumarin hybrid compounds (6 or 7-styryl-3- phenylcoumarin) were designed, synthesized and thirteen compounds were evaluated for their antitumor activities against MCF-7, HCT-28, and K562 tumor cell lines. Among them, compounds 2Z, 2E, 5E, and 7E showed varying degrees of growth inhibition of the above cell lines (IC50: 3.78-19.16 μmol/L). On the basis of the biological results, structure-activity relationships were obtained and discussed.
