66675-23-8Relevant academic research and scientific papers
HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF
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Page/Page column 102, (2015/07/07)
Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.
HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
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Page/Page column 87, (2014/01/18)
Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.
Gold(I)-catalyzed aminohalogenation of fluorinated N′-aryl-N- propargyl amidines for the synthesis of imidazole derivatives under mild conditions
Li, Shan,Li, Zhengke,Yuan, Yafen,Li, Yajun,Zhang, Lisi,Wu, Yongming
, p. 1496 - 1501 (2013/03/14)
A procedure for the synthesis of fluorinated imidazole derivatives from propargyl amidines has been developed. Under gold(I) catalysis, propargyl amidines were converted into 5-fluoromethyl imidazoles in the presence of Selectfluor through a cascade cyclization/fluorination process. In contrast, imidazole-5-carbaldehydes were obtained in high yields when N-iodosuccinimide (NIS) was used as the halogenating reagent. The polarity of the solvent and light had significant impact on the formation of the carbaldehydes. These transformations showed excellent functional-group tolerance. An unfluorinated substrate with an electron-withdrawing group also underwent aminohalogenation to give the corresponding product in good yield. Mechanistic investigation revealed the general pathways of these transformations. Copyright
Photochemical Perfluoroalkylation of Imidazoles
Kimoto, Hiroshi,Fujii, Shozo,Cohen, Louis A.
, p. 2867 - 2872 (2007/10/02)
Imidazole and its derivatives undergo facile trifluoromethylation or perfluoroalkylation, in methanol solution at ambient temperature, following radical dissociation of RFI by γ or UV irradiation.In the case of imidazole, attack occurs preferen
