66679-93-4

Upstream product

• 898050-75-4 3-(3-methoxyphenyl)-2-methylsulfanyl-3H-quinazolin-4-one 
• 34881-38-4 (3-Methoxy-phenyl)-dithiocarbamic acid methyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 66679-67-2 2-hydroazino-3-(3-methoxyphenyl)-3H-quinazolin-4-one 
• 536-90-3 m-Anisidine 
• 56671-19-3 3-(3-methoxyphenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 

Relevant academic research and scientific papers

Synthesis and analgesic, anti-inflammatory activities of 3-(3-methoxyphenyl)-2-substituted amino-quinazolin-4 (3H)-ones

A variety of novel 3-(3-methoxyphenyl)-2- substituted amino-quinazolin- 4(3H)-ones were synthesized by reacting the amino group of 2-hydrazino-3-(3- methoxyphenyl)- quinazolin-4(3H)-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(3- methoxyphenyl)-quinazolin-4(3H)-one was synthesized from 3-methoxy aniline. The title compounds were investigated for analgesic, anti-inflammatory, and ulcerogenic behavior. Among these the compound 2-(1-methyl butylidene- hydrazino)-3-(3-methoxyphenyl)-3H-quinazolin-4-one (AS3) emerged as the most active compound for the analgesic activity, while the compound 2-(1-ethyl propylidene- hydrazino)-3-(3-methyoxyphenyl)-3H-quinazolin- 4- one (AS2) showed most potent anti-inflammatory activity of the series and these compounds are moderately more potent when compared to the reference standard diclofenac sodium. Interestingly the test compounds showed only mild ulcerogenic potential when compared to acetylsalicylic acid. Springer Science+Business Media, LLC 2010.