66682-07-3Relevant academic research and scientific papers
Novel 3, 4, 5- preparation method of methyltrifluorobenzotrifluoride (by machine translation)
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Paragraph 0008-0009; 0018; 0020; 0024; 0028; 0032, (2020/01/14)
Compared with the prior art, the 3, 4, 5 - method disclosed by the invention disclosed. by 3,4 - the invention has the, advantages that, a, large, number of 3, 4, 5 - the raw materials. used in the present, invention avoids the pollution to the environment, the, environmental hazard is reduced, the production cost of, the target compound is, reduced, the economic benefit is; improved, the, yield of, the product is high, and the, operation is simple; and convenient . (by machine translation)
Process for the production of 4-amino-3,5-dichlorobenzotrifluoride with high purity commercial products being obtained in parallel
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Page/Page column 5-8, (2008/06/13)
Process for the production of 4-amino-3,5-dichlorobenzotrifluoride comprising the stages:A) chlorination of 4-chlorobenzotrichloride, in the presence of a Lewis acid, in order to obtain a mixture of 3,4-dichlorobenzotrichloride and 3,4,5-trichlorobenzotrichloride and other chlorine derivatives by performing the reaction in such a manner as to obtain in the mixture of reaction products a quantity of 3,4,5-trichlorobenzotrichloride of greater than 10% by weight and preferably of between 20% and 30% by weight and a concentration of 3,4-trichlorobenzotrichloride of less than 90% by weight and preferably of between approx. 55% and 75% by weight, relative to the total weight of the chlorinated derivatives;B) fluorination with hydrofluoric acid of the mixture of chlorination products as obtained in stage A) in order to obtain the corresponding benzotrifluorides; andC) separation by distillation of the mixture of products of stage B) in order to obtain 3,4,5-trichlorobenzotrifluoride or an isomeric mixture of 3,4,5- and 2,4,5-trichlorobenzotrifluoride; andD) amination of 3,4,5-trichlorobenzotrifluoride or of said isomeric mixture.
