666822-10-2Relevant academic research and scientific papers
Useful Precursors for Synthesis of Some New Azolo[3,4-d]pyridiazines, Azolo[1,5-a]pyrimidines, Azolo[5,1-c]triazines, Pyrazoles, and Benzo[b][l,4]diazepine
Abdelhamid, Abdou O.,Fahmi, Abdelgawad A.,Baaiu, Basma S.
, p. 1917 - 1927 (2016)
Pyrazolo[3,4-d]pyridazines, isoxazolo[3,4-d]pyridazines, azolo[1,5-a]pyrimidines, azolo[5,1-c]triazines, pyrazoles, and benzo[b][l,4]diazepine were synthesized from the appropriate hydrazonoyl halides, hydroximoyl halides, heterocyclic amines, diazotized heterocyclic amines, arenediazonium chlorides, and o-phenylenediamines with appropriate of sodium 3-(5-bromobenzofuran-2-yl)-3-oxoprop-1-en-1-olate or 1-(5-bromobenzofuran-2-yl)-3-(dimethylamino)prop-2-en-1-one. The newly synthesized compounds were elucidated by elemental analyses, spectral data, and alternative synthesis whenever possible.
Microwave-promoted heck and suzuki coupling reactions of new 3-(5-bromobenzofuranyl)pyrazole in aqueous media
Dawood, Kamal M.,Darweesh, Ahmed F.,Shaaban, Mohamed R.,Farag, Ahmad M.
, p. 348 - 358 (2018)
Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions of 3-(5-bromobenzofuran-2-yl)-1H-pyrazole with various arylboronic acids and terminal olefins, respectively, were investigated using a benzothiazole-oxime palladium(II) complex, under both thermal and microwave-irradiation conditions, in an open vessel, using aqueous solvent. The benzothiazole-oxime-based Pd(II) complex was found to be an efficient, and highly active pre-catalyst for the cross-coupling reactions, and for the preparation of new C-C cross-coupled compounds of potential biological interest which are difficult to obtain using other synthetic routes.
