666831-18-1

Basic information

• Product Name: 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[[(3R,4S)-3-(acetyloxy)-4-[(methylthio)methyl]-1-pyrrolidinyl]methyl]-1,5 -dihydro-5-[(phenylmethoxy)methyl]-
• CAS NO: 666831-18-1
• Molecular Formula: C23H28N4O4S
• Molecular Weight: 456.566
• Mol File: 666831-18-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[[(3R,4S)-3-(acetyloxy)-4-[(methylthio)methyl]-1-pyrrolidinyl]methyl]-1,5 -dihydro-5-[(phenylmethoxy)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[[(3R,4S)-3-(acetyloxy)-4-[(methylthio)methyl]-1-pyrrolidinyl]methyl]-1,5 -dihydro-5-[(phenylmethoxy)methyl]-(666831-18-1)
• EPA Substance Registry System: 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[[(3R,4S)-3-(acetyloxy)-4-[(methylthio)methyl]-1-pyrrolidinyl]methyl]-1,5 -dihydro-5-[(phenylmethoxy)methyl]-(666831-18-1)

Safety Data

• Hazardous Substances Data: 666831-18-1(Hazardous Substances Data)

Upstream product

• 635319-09-4 tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 666831-26-1 (3R,4S)-tert-butyl 3-hydroxy-4-((methylthio)methyl)pyrrolidine-1-carboxylate 
• 666831-17-0 (3R,4S)-1-[(7-benzyloxymethyl-6-tert-butoxy-9-deazapurin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine hydrochloride 
• 666831-24-9 tert-butyl (3R,4R)-3-hydroxy-4-[(methanesulfonyloxy)methyl]pyrrolidine-1-carboxylate 

Downstream Products

• 653592-04-2 (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((methylthio)methyl)pyrrolidin-3-ol 
• 666831-19-2 (3R,4S)-1-[(7-benzyloxymethyl-9-deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine 

Relevant articles and documents

Second generation transition state analogue inhibitors of human 5′-methylthioadenosine phosphorylase

The polyamine biosynthetic pathway is a therapeutic target for proliferative diseases because cellular proliferation requires elevated levels of polyamines. A byproduct of the synthesis of spermidine and spermine is 5′-methylthioadenosine (MTA). In humans