4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[[(3R,4S)-3-(acetyloxy)-4-[(methylthio)methyl]-1-pyrrolidinyl]methyl]-1,5 -dihydro-5-[(phenylmethoxy)methyl]-

Base Information

Chemical Name:4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[[(3R,4S)-3-(acetyloxy)-4-[(methylthio)methyl]-1-pyrrolidinyl]methyl]-1,5 -dihydro-5-[(phenylmethoxy)methyl]-
CAS No.:666831-18-1
Molecular Formula:C23H28N4O4S
Molecular Weight:456.566
Hs Code.:

4H-Pyrrolo[3,2-d]pyrimidin-4-one,
7-[[(3R,4S)-3-(acetyloxy)-4-[(methylthio)methyl]-1-pyrrolidinyl]methyl]-1,5
-dihydro-5-[(phenylmethoxy)methyl]-

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Chemical Property of 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[[(3R,4S)-3-(acetyloxy)-4-[(methylthio)methyl]-1-pyrrolidinyl]methyl]-1,5 -dihydro-5-[(phenylmethoxy)methyl]-

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Technology Process of 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[[(3R,4S)-3-(acetyloxy)-4-[(methylthio)methyl]-1-pyrrolidinyl]methyl]-1,5 -dihydro-5-[(phenylmethoxy)methyl]-

There total 6 articles about 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[[(3R,4S)-3-(acetyloxy)-4-[(methylthio)methyl]-1-pyrrolidinyl]methyl]-1,5 -dihydro-5-[(phenylmethoxy)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: (3R,4S)-1-[(6-tert-butoxy-7-benzyloxymethyl-9-deazapurin-9-yl)methyl]-3-acetoxy-4-(methylthiomethyl)pyrrolidine

: 666831-18-1
(3R,4S)-1-acetoxy-[(7-benzyloxymethyl-6-tert-butoxy-9-deazahypoxanthin-9-yl)methyl]-4-methylthiomethylpyrrolidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 666831-26-1
(3R,4S)-tert-butyl 3-hydroxy-4-((methylthio)methyl)pyrrolidine-1-carboxylate

: 666831-18-1
(3R,4S)-1-acetoxy-[(7-benzyloxymethyl-6-tert-butoxy-9-deazahypoxanthin-9-yl)methyl]-4-methylthiomethylpyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 422 mg / aq. HCl / methanol

2: 78 percent / NaCNBH₃ / methanol / 20 °C

3: 1.35 g / DMAP; triethylamine / CH₂Cl₂ / 0.25 h / 20 °C

4: 800 mg / TFA / CH₂Cl₂ / 20 °C

With hydrogenchloride; dmap; sodium cyanoborohydride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/jm050269z

Reference yield:

: 666831-24-9
tert-butyl (3R,4R)-3-hydroxy-4-[(methanesulfonyloxy)methyl]pyrrolidine-1-carboxylate

: 666831-18-1
(3R,4S)-1-acetoxy-[(7-benzyloxymethyl-6-tert-butoxy-9-deazahypoxanthin-9-yl)methyl]-4-methylthiomethylpyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 600 mg / dimethylformamide / 20 °C

2: 422 mg / aq. HCl / methanol

3: 78 percent / NaCNBH₃ / methanol / 20 °C

4: 1.35 g / DMAP; triethylamine / CH₂Cl₂ / 0.25 h / 20 °C

5: 800 mg / TFA / CH₂Cl₂ / 20 °C

With hydrogenchloride; dmap; sodium cyanoborohydride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050269z