666831-27-2Relevant academic research and scientific papers
Second generation transition state analogue inhibitors of human 5′-methylthioadenosine phosphorylase
Evans, Gary B.,Furneaux, Richard H.,Lenz, Dirk H.,Painter, Gavin F.,Schramm, Vern L.,Singh, Vipender,Tyler, Peter C.
, p. 4679 - 4689 (2007/10/03)
The polyamine biosynthetic pathway is a therapeutic target for proliferative diseases because cellular proliferation requires elevated levels of polyamines. A byproduct of the synthesis of spermidine and spermine is 5′-methylthioadenosine (MTA). In humans
INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES
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Page 51-52, (2008/06/13)
The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5'-methylthioadenosine phosphorylases (MTAP), 5'-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds
