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66684-59-1

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66684-59-1 Usage

General Description

2,3-Difluoro-4-nitroanisole is a chemical compound with the molecular formula C7H6F2NO3. It is an organic nitro compound that contains both fluorine and nitro functional groups. 2,3-Difluoro-4-nitroanisole is used as an intermediate in the manufacture of pharmaceuticals and agrochemicals. It is also used as a building block in the synthesis of other organic compounds. 2,3-Difluoro-4-nitroanisole has a pale yellow color and a slightly sweet odor. It is important to handle this chemical with caution, as it may be harmful if ingested, inhaled, or in contact with skin.

Check Digit Verification of cas no

The CAS Registry Mumber 66684-59-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,6,8 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 66684-59:
(7*6)+(6*6)+(5*6)+(4*8)+(3*4)+(2*5)+(1*9)=171
171 % 10 = 1
So 66684-59-1 is a valid CAS Registry Number.

66684-59-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,3-Difluoro-4-nitroanisole

1.2 Other means of identification

Product number -
Other names 2,3-difluoro-1-methoxy-4-nitrobenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66684-59-1 SDS

66684-59-1Relevant articles and documents

Constructing a catalytic cycle for c-f to c-x (x = o, s, n) bond transformation based on gold-mediated ligand nucleophilic attack

Hu, Ji-Yun,Zhang, Jing,Wang, Gao-Xiang,Sun, Hao-Ling,Zhang, Jun-Long

supporting information, p. 2274 - 2283 (2017/01/16)

A tricoordinated gold(I) chloride complex, tBuXantphosAuCl, supported by a sterically bulky 9,9-dimethyl-4,5-bis(di-Tert-butylphosphino)xanthene ligand (tBuXantphos) was synthesized. This complex features a remarkably longer Au?Cl bond length [2.632(1) ?] than bicoordinated linear gold complexes (2.27-2.30 ?) and tricoordinated XantphosAuCl [2.462(1) ?]. Single-crystal Xray diffraction analysis of a cocrystal of tBuXantphosAuCl and pentafluoronitrobenzene (PFNB) and UV-vis spectroscopic titration experiments revealed the existence of an anion-φ interaction between the Cl anion ligand and PFNB. Stoichiometric reaction between PFNB and tBuXantphosAuOtBu, after replacement of Cl by a more nucleophilic tBuO anion ligand, showed higher reactivity and para selectivity in the transformation of C-F to C-OtBu bond, distinctively different from that when only KOtBu was used (ortho selectivity) under the identical condition. Mechanistic studies including density functional theory calculations suggested a gold-mediated nucleophilic ligand attack of the C?F bond pathway via an SNAr process. On the basis of these results, using trimethylsilyl derivatives TMS-X (X = OMe, SEt, NEt) as the nucleophilic ligand source and the fluorine acceptor, catalytic transformation of the C-F bond of aromatic substrates to the C-X (X = O, S, N) bond was achieved with tBuXantphosAuCl as the catalyst (up to 20 turnover numbers).

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