666861-80-9Relevant academic research and scientific papers
Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors
Hu, Xubo,Zhu, Jinge,Srivathsan, Sumant,Pei, Dehua
, p. 77 - 79 (2007/10/03)
A new class of methionine aminopeptidase (MetAP) inhibitors, which contain an internal hydroxamate (N-acyl-N-alkylhydroxylamine) core as the metal-chelating group, has been designed, synthesized, and tested. The compounds exhibited reversible, competitive inhibition against Escherichia coli MetAP as well as human MetAP-1 and MetAP-2. The most potent inhibitor had a Ki value of 2.5 μM and >20-fold selectivity toward E. coli MAP.
