66642-20-4

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 622-33-3 N-benzyloxyamine 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 115-11-7 isobutene 
• 54837-14-8 2-(benzyloxyamino)acetic acid 

Downstream Products

• 212058-73-6 [Benzyloxy-(4-trifluoromethyl-benzoyl)-amino]-acetic acid tert-butyl ester 
• 212058-69-0 C₁₇H₁₈N₂O₄ 
• 212058-68-9 C₁₆H₁₆N₂O₄ 
• 666861-89-8 (1-{benzyloxy-[(2-pyridin-2-yl-ethylcarbamoyl)-methyl]-carbamoyl}-pentyl)-carbamic acid tert-butyl ester 
• 666861-88-7 (1-{benzyloxy-[(2-pyridin-2-yl-ethylcarbamoyl)-methyl]-carbamoyl}-3-methylsulfanyl-propyl)-carbamic acid tert-butyl ester 
• 666861-82-1 2-benzyloxyamino-N-(2-pyridin-2-yl-ethyl)-acetamide 
• 54837-14-8 2-(benzyloxyamino)acetic acid 
• 666861-80-9 [benzyloxy-(2-tert-butoxycarbonylamino-4-methylsulfanyl-butyryl)-amino]-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

SPECIFIC SYNTHETIC CHIMERIC XENONUCLEIC ACID GUIDE RNA; s(XNA-gRNA) FOR ENHANCING CRISPR MEDIATED GENOME EDITING EFFICIENCY

The invention provides xenonucleic acids and synthetic chimeric xenonucleic acid guide RNA; s(XNA-gRNA) for enhancing crispr mediated genome editing efficiency. The invention also provides methods and compositions for inducing CRISPR/Cas-based gene editin

COMPOSITIONS, METHODS, AND DEVICES FOR CAPTURING PHOSPHATE FROM WATER

The present disclosure provides compositions, methods, and devices for sensing, detecting, and/or selectively capturing phosphate from water. An exemplary method includes: contacting a ligand or a rare earth metal complex of a ligand as described herein with an aqueous phosphate-containing medium at a pH of 5 to 12 under conditions sufficient to bind phosphate (e.g., reversibly bind phosphate). In certain embodiments, the method further includes releasing the bound phosphate by contacting the bound phosphate complex with an aqueous medium at a pH of 0 to 4 under conditions sufficient to release the bound phosphate.

Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors

A new class of methionine aminopeptidase (MetAP) inhibitors, which contain an internal hydroxamate (N-acyl-N-alkylhydroxylamine) core as the metal-chelating group, has been designed, synthesized, and tested. The compounds exhibited reversible, competitive inhibition against Escherichia coli MetAP as well as human MetAP-1 and MetAP-2. The most potent inhibitor had a Ki value of 2.5 μM and >20-fold selectivity toward E. coli MAP.

Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use

The present invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5, R6, A, X, m and n have the meanings indicated in the claims. The compounds of the formula I are val

Synthesis and aldose reductase inhibitory activity of new N- (benzyloxy) glycine derivatives

This paper reports the synthesis and aldose reductase (AR) inhibitory properties of some N-(benzyloxy) glycine derivatives (compounds 2-6), structurally related to the previously described N-(aroyl)-N- (arylmethyloxy)glycines A which had proved to possess an appreciable AR inhibitory activity. In compounds 2-5, spacers of different lengths and degrees of rigidity were inserted between the phenyl ring and the carbonyl group of type A derivatives; compound 6 differs from the most active type A derivative (compound 1) in the replacement of the methoxy moiety in thepara position of the benzoyl side-chain with a group with different electronic characteristics, such as the trifluoromethyl moiety. Biological results indicated that among compounds 2-5 only derivative 3, which presents a CH2CH2 spacer between the phenyl and the carbonyl moiety, proved to possess AR inhibitory properties analogous to those of 1, while all the other compounds proved to be devoid of any significant activity. Furthermore, compound 6 showed an inhibitory activity about 3 times lower than that of 1.