66692-98-6Relevant academic research and scientific papers
Trifluoromethylation of aromatic isoxazoles: Regio- and diastereoselective route to 5-trifluoromethyl-2-isoxazolines
Kawai, Hiroyuki,Tachi, Kentaro,Tokunaga, Etsuko,Shiro, Motoo,Shibata, Norio
supporting information; scheme or table, p. 7803 - 7806 (2011/10/05)
It all adds up: The activation of aromatic isoxazoles with a nitro group at the 4-position has enabled the first regio- and diastereoselective trifluoromethylation at the 5-position of isoxazoles by nucleophilic addition using Me3SiCF3 (see scheme; DMF=N,N′- dimethylformamide). The process was demonstrated with a broad range of 3,5-aromatic, heteroaromatic and aliphatic substrates.
SYNTHESIS AND PROPERTIES OF AZOLES AND THEIR DERIVATIVES. PART XX. STUDIES ON THE THERMOLYSIS OF REGIO AND STEREOISOMERIC DIARYLNITRO-Δ2-ISOXAZOLINES
Baranski, Andrzej,Cholewka, Elzbieta
, p. 483 - 494 (2007/10/02)
Thermolysis of stereoisomeric 3,5-diaryl-4-nitro-Δ2-isoxazolines 1, 3, depending on the applied solvent, leads to 3,5-diarylisoxazoles 4 or mixtures of 3,5-diarylisoxazoles 4 and 3,5-diaryl-4-nitroisoxazoles 6.Under similar conditions, 3,4-diar
SYNTHESIS AND PROPERTIES OF AZOLS AND THEIR DERIVATIVES. PART XII. REGIO- AND STEREOCHEMISTRY IN CYCLOADDITION REACTIONS OF β-NITROSTYRENES WITH BENZONITRILE n-OXIDE
Baranski, Andrzej
, p. 107 - 119 (2007/10/02)
1,3-Dipolar cycloaddition of trans-β-nitrostyrenes 1a-d to benzonitrile N-oxide 2 has been investigated.It was found that regioisomeric 4,5-dihydro-1,2-oxazoles were formed as primary products due to two possible orientations of reactants in the transitio
SYNTHESIS AND PROPERTIES OF AZOLES AND THEIR DERIVATIVES. 10. SYNTHESIS OF 3,5-DIARYL-4-NITROISOXAZOLES
Baranski, A.
, p. 153 - 156 (2007/10/02)
A method was proposed for the synthesis of 3,5-diaryl-4-nitroisoxazoles entailing the bromination of potassium salts of the corresponding 3,5-diaryl-Δ2-isoxazolinyl-4-nitronic acids.The method may be used for the conversions of both the trans and cis isomers of 3,5-disubstituted 4-nitro-Δ2-isoxazolines.
