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Meerwein Saponification of Alkyl 3-Oxoalkanoates in the Gas Chromatograph
Thoma, Heinz,Spiteller, Gerhard
, p. 1237 - 1248 (2007/10/02)
Alkyl 3-oxoalkanoates decompose by unevitable traces of water in the gas chromatograph to yield the corresponding methyl ketones and alcohols (Meerwein saponification).Decomposition occurs in the hot injector (T= 270 deg C) of the gas chromatograph and also on glass capillary columns (T> 160 deg C).Decomposition in routine work can be avoided by preparing the corresponding 3-trimethylsilyl enol ethers.
