66711-54-4Relevant academic research and scientific papers
Antifungal Activities of 2,4,6-Trihydroxyacylophenones and Related Compounds
Mizobuchi, Shigeyuki,Sato, Yuko
, p. 719 - 724 (2007/10/02)
The antifungal activities of sixty two 2,4,6-trihydroxyacylophenones and related compounds against Trichophyton spp. and other fungi were investigated to study their structure-activity relationship.It was found that the activities of these compounds were closely related to the length of the acyl and alkyl chains attached to the 1,3,5-trihydroxybenzene moiety.Among the compounds tested, 2,4,6-trihydroxy-3-nonylacetophenone (V-7) showed the highest activity against Trichophyton spp., with MICs being 1.57 μg/ml, and was more active than amphotericin B.
