66716-60-7Relevant academic research and scientific papers
and Annulation Reactions of α-(Phenylthio) Dicarbonyl Electrophiles with Bis(trimethylsilyl) Enol Ethers: Synthesis of Highly Functionalized Medium Ring Cycles
Molander, Gary A.,Eastwood, Paul R.
, p. 8382 - 8393 (2007/10/02)
The and annulations of bis(trimethylsilyl) enol ethers with 1,4- and 1,5-dicarbonyl electrophiles bearing α-phenylthio substituents leads to the formation of bicyclic and ethers with good regiochemical and stereochemical control.Subsequent oxidation of the phenylthio moiety followed by reduction with SmI2 constitutes a high-yielding and regioselective process for cleavage of the bridging ether linkage.The overal strategy provides a synthetic pathway for the synthesis of highly functionalized medium ring carbocycles.
