66724-34-3

Upstream product

• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 
• 106-54-7 p-Chlorothiophenol 
• 790-15-8 6-chloro-2-(4-chloro-phenyl)-thiochromen-4-one 

Relevant academic research and scientific papers

Antimalarial and anticoccidial activity of 3-aryl-7-chloro-3,4-dihydroacridine-1,9-(2H,10H)-diones. 1-Imines, 1-amines, 1-oximes, 1-hydrazones and related compounds

Out of more than 130 synthesized derivatives of floxacrine and of 10-deoxyfloxacrine, such as 3-(4-trifluoromethyl-phenyl) or 3-(4-chlorophenyl)-7-chloro-10-hydroxy- or -10-deoxy-3,4-dihydroacridine-1,9(2H,10H)-dione 1-imines and 1-hydrazones, more than 4

A new class of antimalarial drugs: Derivatives of benzothiopyrans

A series of substituted benzothiopyrans was synthesized and examined for antimalarial activity. Some were found to be active and curative at dose levels of 160 - 360 mg/kg against Plasmodium berghei in mice. A few observations concerning structure-activity relationships were made. The benzothiopyrans were prepared by treatment of either the gem-dichloro- or the thionothioflavone intermediate with various primary amines. The thionothioflavone intermediates were made from thioflavones. Condensation of thiophenols with benzoyl acetates gave the thioflavones.