790-15-8Relevant academic research and scientific papers
Antimalarial and anticoccidial activity of 3-aryl-7-chloro-3,4-dihydroacridine-1,9-(2H,10H)-diones. 1-Imines, 1-amines, 1-oximes, 1-hydrazones and related compounds
Winkelmann,Raether
, p. 647 - 661 (2007/10/02)
Out of more than 130 synthesized derivatives of floxacrine and of 10-deoxyfloxacrine, such as 3-(4-trifluoromethyl-phenyl) or 3-(4-chlorophenyl)-7-chloro-10-hydroxy- or -10-deoxy-3,4-dihydroacridine-1,9(2H,10H)-dione 1-imines and 1-hydrazones, more than 4
A new class of antimalarial drugs: Derivatives of benzothiopyrans
Razdan,Bruni,Mehta,Weinhardt,Papanastassiou
, p. 643 - 649 (2007/10/05)
A series of substituted benzothiopyrans was synthesized and examined for antimalarial activity. Some were found to be active and curative at dose levels of 160 - 360 mg/kg against Plasmodium berghei in mice. A few observations concerning structure-activity relationships were made. The benzothiopyrans were prepared by treatment of either the gem-dichloro- or the thionothioflavone intermediate with various primary amines. The thionothioflavone intermediates were made from thioflavones. Condensation of thiophenols with benzoyl acetates gave the thioflavones.
