66724-77-4Relevant academic research and scientific papers
A new class of antimalarial drugs: Derivatives of benzothiopyrans
Razdan,Bruni,Mehta,Weinhardt,Papanastassiou
, p. 643 - 649 (2007/10/05)
A series of substituted benzothiopyrans was synthesized and examined for antimalarial activity. Some were found to be active and curative at dose levels of 160 - 360 mg/kg against Plasmodium berghei in mice. A few observations concerning structure-activity relationships were made. The benzothiopyrans were prepared by treatment of either the gem-dichloro- or the thionothioflavone intermediate with various primary amines. The thionothioflavone intermediates were made from thioflavones. Condensation of thiophenols with benzoyl acetates gave the thioflavones.
